NERVES AND ANGIOGENESIS IN AMPHIBIAN LIMB REGENERATION
NERVES AND ANGIOGENESIS IN AMPHIBIAN LIMB REGENERATION
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DOI：
10.1038/257224a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
WOLPERT, L
中科院分区：
文献类型：
--
作者：
SMITH, AR;WOLPERT, L
在过去的150年里，由于两栖动物肢体再生的神经的要求被证明，有相当大的进展，在指定的现象的性质，但几乎没有在理解的网站或性质的神经元effect 1。如果早期进行去神经支配，截肢将不会再生，甚至可能发生退化;在再生的后期阶段，当芽基形成时，再生不会被去神经支配所阻止，尽管至少在蝾螈中，体积的增长受到抑制，而长度和形态发生的增长继续2，3。对神经元依赖性的研究表明，任何神经都可以提供营养影响，既不需要中枢也不需要反射回路，并且在截肢表面需要阈值数量的神经4。神经营养剂并不决定再生的性质，而只是其生长特性4，这是由许多生物化学研究证实的，所有这些研究都表明神经非特异性地影响大分子合成和细胞分裂5，6。
IN the past 150 yr, since the requirement of nerves for amphibian limb regeneration was demonstrated, there has been considerable progress in specifying the nature of the phenomenon but virtually none in understanding the site or nature of the neuronal effect1. If denervation is carried out early, amputated limbs will not regenerate and may even undergo regression; at later stages in regeneration, when a blastema has formed, regeneration is not prevented by denervation, although in the newt at least, growth in volume is inhibited while growth in length and morphogenesis continue2,3. Studies on the neuronal dependence have shown that any nerve can provide the trophic influence, that neither central nor reflex circuitry is required, and that a threshold number of nerves at the amputation surface is needed4. The neurotrophic agents do not determine the nature of the regenerate but only its growth properties4, and this is borne out by many biochemical studies, all of which suggest that nerves nonspecifically affect macromolecular synthesis and cell division5,6.