Saturated fat and cardiovascular disease: Importance of inter-individual variation in the response of serum low-density lipoprotein cholesterol
Saturated fat and cardiovascular disease: Importance of inter-individual variation in the response of serum low-density lipoprotein cholesterol
复制标题
饱和脂肪和心血管疾病：血清低密度脂蛋白胆固醇反应中个体差异的重要性
DOI：
10.1017/s0029665124000107
复制
发表时间：
2024
影响因子：
7
通讯作者：
Griffin B
中科院分区：
文献类型：
--
作者：
Griffin B
本文综述了饮食中饱和脂肪酸（SFA）在心血管疾病（CVD）发展中的作用的历史，以及支持指南中用不饱和脂肪酸去除和替代SFA的证据的争议和共识。该综述还将研究是否存在，起源和对心血管疾病风险的影响，血清LDL-胆固醇的变异性，以响应这些指南。虽然限制SFA对CVD风险的有效性的支持证据的质量引起了争议，但这有助于增加对SFA，LDL胆固醇和CVD之间相互关系的理解，并加强对这种饮食建议的信心。然而，在对这种饮食变化的反应中，血清LDL-C存在显著的个体间差异。这种变化的起源是多因素的，涉及饮食和代谢特征。如果可以确定LDL反应性基础上更复杂代谢特征的血清生物标志物，这将对这些饮食指南针对LDL反应者产生重大影响，以最大限度地提高其心血管健康的益处。
The aim of this review is to provide an overview of the history in support of the role of dietary saturated fatty acids (SFA) in the development of cardiovascular disease (CVD), and the controversy and consensus for the evidence in support of guidelines to remove and replace SFA with unsaturated fatty acids. The review will also examine the existence, origins, and implications for CVD risk of variability in serum LDL-cholesterol in response to these guidelines. While the quality of supporting evidence for the efficacy of restricting SFA on CVD risk has attracted controversy, this has helped to increase understanding of the inter-relationships between SFA, LDL-cholesterol and CVD, and reinforce confidence in this dietary recommendation. Nevertheless, there is significant inter-individual variation in serum LDL-C in response to this dietary change. The origins of this variation are multi-factorial and involve both dietary and metabolic traits. If serum biomarkers of more complex metabolic traits underlying LDL-responsiveness can be identified, this would have major implications for the targeting of these dietary guidelines to LDL-responders, to maximise the benefit to their cardiovascular health.