Iron-Catalyzed Aerobic Oxidation of Alcohols: Lower Cost and Improved Selectivity
Iron-Catalyzed Aerobic Oxidation of Alcohols: Lower Cost and Improved Selectivity
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DOI：
10.1021/acs.oprd.8b00374
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发表时间：
2019-05-01
影响因子：
3.4
通讯作者：
Ma, Shengming
中科院分区：
文献类型：
--
作者：
Jiang, Xingguo;Liu, Jinxian;Ma, Shengming
已经开发出使用催化量的 Fe(NO3)(3) 中心点 9H(2)O、4-OH-TEMPO 和 NaCl 将醇氧化成醛或酮的有氧氧化反应。与本课题组开发的以前的TEMPO催化体系相比，使用4-OH-TEMPO的新方案在工业规模上更便宜，并且以更高的选择性完成了转化，特别是对于脂肪醇向醛的转化。 α,β-不饱和炔醛或炔酮可以由炔丙醇有效合成，但文献中对此的研究较少。
An aerobic oxidation reaction of alcohols toward aldehydes or ketones using catalytic amounts of Fe(NO3)(3)center dot 9H(2)O, 4-OH-TEMPO, and NaCl has been developed. Compared with the former catalytic system with TEMPO developed in this group, the new protocol using 4-OH-TEMPO, which is much cheaper on an industrial scale, accomplished the transformation with a higher selectivity, especially for aliphatic alcohols toward aldehydes. alpha,beta-Unsaturated alkynals or alkynones can be efficiently synthesized from propargyl alcohols, which has been much less studied in the literature.