Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers.
Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers.
复制标题
日本男性工人膳食盐摄入量与高血压易感性基因多态性与血压之间的相互作用的关联。
DOI：
10.1007/s10157-016-1315-3
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发表时间：
2016
期刊：
影响因子：
2.3
通讯作者：
Matsuo S.
中科院分区：
文献类型：
--
作者：
Imaizumi T;Ando M;Nakatochi M;Maruyama S;Yasuda Y;Honda H;Kuwatsuka Y;Kato S;Kondo T;Iwata M;Nakashima T;Yasui H;Takamatsu H;Okajima H;Yoshida Y;Matsuo S.
研究背景血压受遗传因素和饮食习惯的影响。本研究的目的是检查饮食中的盐的消耗量和单核苷酸多态性（SNP）对血压（BP）的影响。MethodsThis是一个横断面分析的2728名男性参与者谁参加了健康检查，在2009年。平均膳食盐消耗量估计使用电子收集的膳食购买数据从食堂。进行多变量分析，调整临床相关因素，以检查盐摄入量、SNP以及盐摄入量与每个SNP之间的相互作用是否对BP有影响。本研究探讨SNPs AGTrs699（Met235Thr）、ADD1rs4961（Gly460Trp）、NPPArs5063（Val32Met）、GPX1rs1050450（Pro198Leu）和AGTR1rs5186（A1166C）与高血压和盐敏感性的关系。盐摄入量和SNPs与收缩压之间的相互作用在NPPArs5063（Val32Met）中显示出显著相关（P= 0.023），在rs4961和rs1050450中显示出边缘趋势显著性（P分别为0.060和0.067）。饮食中的盐摄入量和遗传变异可以预测高血压的高风险。
BackgroundBlood pressure is influenced by hereditary factors and dietary habits. The objective of this study was to examine the effect of dietary salt consumption and single-nucleotide polymorphisms (SNPs) on blood pressure (BP).MethodsThis was a cross-sectional analysis of 2728 male participants who participated in a health examination in 2009. Average dietary salt consumption was estimated using electronically collected meal purchase data from cafeteria. A multivariate analysis, adjusting for clinically relevant factors, was conducted to examine whether the effect on BP of salt consumption, SNPs, and interaction between salt consumption and each SNP. This study examined the SNPsAGTrs699 (Met235Thr),ADD1rs4961 (Gly460Trp),NPPArs5063 (Val32Met),GPX1rs1050450 (Pro198Leu), andAGTR1rs5186 (A1166C) in relation to hypertension and salt sensitivity.ResultsBP was not significantly associated with SNPs or salt consumption. The interaction between salt consumption and SNPs with systolic BP showed a significant association inNPPArs5063 (Val32Met) (P= 0.023) and a marginal trend toward significance in rs4961 and rs1050450 (P= 0.060 and 0.067, respectively).ConclusionThe effect of salt consumption on BP differed by genotype. Dietary salt consumption and genetic variation can predict a high risk of hypertension.