Association between ITGA2 C807T polymorphism and gastric cancer risk
Association between ITGA2 C807T polymorphism and gastric cancer risk
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ITGA2 C807T 多态性与胃癌风险的关联
DOI：
10.3748/wjg.v17.i23.2860
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发表时间：
2011-06-21
影响因子：
4.3
通讯作者：
Wang, Xue-Rong
中科院分区：
文献类型：
--
作者：
Chen, Jie;Liu, Nan-Nan;Wang, Xue-Rong
目的：探讨ITGA2基因多态性对胃癌发病的影响。方法：采用以医院为基础的病例对照研究，包括307例胃癌患者和307例年龄和性别匹配的对照组。采用聚合酶链反应-限制性片段长度多态性测定法进行基因型鉴定。结果：病例中野生型和变异型的频率与对照组有显著差异（P = 0.019）。与野生基因型CC个体相比，变异基因型（CT + TT）受试者发生胃癌的风险显著增高（校正优势比= 1.57,95% CI = 1.13 ~ 2.17, P = 0.007）。在分层分析中，胃癌风险升高在年龄在50 ~ 58岁的老年人、不吸烟者和农村人群中尤为明显。进一步的分析显示，在胃癌患者的亚分析中，变异基因型与肿瘤分化差和邻近器官侵犯有关。结论：ITGA2基因C807T多态性可能与胃癌发生风险增高、胃癌分化及侵袭有关。(C) 2011年白石登。版权所有。
AIM: To evaluate the impact of the ITGA2 gene polymorphism on gastric cancer risk.METHODS: A hospital-based case-control study was conducted, including 307 gastric cancer patients and 307 age- and gender-matched control subjects. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism assay.RESULTS: The frequencies of the wild and variant genotypes in cases were significantly different from those of controls (P = 0.019). Compared with individuals with the wild genotype CC, subjects with the variant genotypes (CT + TT) had a significantly higher risk of gastric cancer (adjusted odds ratio = 1.57, 95% CI = 1.13-2.17, P = 0.007). In stratified analyses, the elevated gastric cancer risk was especially evident in older individuals aged > 58 years, nonsmokers and rural subjects. Further analyses revealed that the variant genotypes were associated with poor tumor differentiation and adjacent organ invasion in the sub-analysis of gastric cancer patients.CONCLUSION: The ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer. (C) 2011 Baishideng. All rights reserved.