Bimodal Distribution of Polyunsaturated Fatty Acids in Schizophrenia Suggests Two Endophenotypes of the Disorder
Bimodal Distribution of Polyunsaturated Fatty Acids in Schizophrenia Suggests Two Endophenotypes of the Disorder
复制标题
DOI：
10.1016/j.biopsych.2011.02.011
复制
发表时间：
2011-07-01
影响因子：
10.6
通讯作者：
Lingjaerde, Odd
中科院分区：
文献类型：
--
作者：
Bentsen, Havard;Solberg, Dag K.;Lingjaerde, Odd
背景：关于精神分裂症患者红细胞中多不饱和脂肪酸（PUFA）是否呈双峰分布的证据存在争议。本研究的目的是检查PUFA的分布，以及它的链接到合理的因果factors.Methods：一个为期16周的队列研究和病例对照研究的一部分，随机对照试验。99例DSM-IV精神分裂症，情感性精神障碍，或精神分裂症样障碍，年龄18至39岁，连续纳入9家挪威医院的精神科入院。其中97名患者和20名健康对照受试者的脂肪酸进行了测量。主要结果测量是双峰检验统计量T，评估卡方（2）检验的可能性的一个或两个正态分布的PUFA.Results：在基线时，多不饱和脂肪酸的水平是非常显着的双峰分布患者。三分之一的患者构成了一组（低PUFA），其PUFA水平为高PUFA患者和健康对照组的五分之一（p <0.001），没有差异。双峰型主要由二十二碳六烯酸和花生四烯酸组成。16周后证实为双峰。在这两种情况下，α-生育酚都是PUFA的可靠预测因子。去饱和酶和延伸酶指数在PUFA组之间存在差异。吸烟，性别，抗精神病药物，饮食因素没有解释双峰distribution.Conclusions：红细胞PUFA双峰分布在急性精神分裂症和情感障碍患者。低PUFA组中氧化还原调节或长链PUFA合成的内源性缺陷可以解释我们的发现。
Background: There is conflicting evidence of whether polyunsaturated fatty acids (PUFA) in red blood cells are bimodally distributed in schizophrenia. The purpose of this study was to examine the distribution of PUFA, as well as its links to plausible causal factors.Methods: A 16-week cohort study and a case-control study as part of a randomized controlled trial. Ninety-nine patients with DSM-IV schizophrenia, schizoaffective disorder, or schizophreniform disorder, aged 18 to 39, were consecutively included at admission to psychiatric departments of nine Norwegian hospitals. Fatty acids were measured in 97 of these patients and in 20 healthy control subjects. The primary outcome measure was the bimodality test statistic T, assessed by a chi(2) test of the likelihood of one or two normal distributions of PUFA.Results: At baseline, levels of polyunsaturated fatty acids were highly significantly bimodally distributed among patients. One third of patients constituted a group (low PUFA) who had PUFA levels at one fifth (p < .001) of those in high PUFA patients and healthy control subjects, which did not differ. Bimodality was mainly accounted for by docosahexaenoic acid and arachidonic acid. Bimodality was confirmed after 16 weeks. alpha-tocopherol was a robust predictor of PUFA at both occasions. Desaturase and elongase indexes differed between PUFA groups. Smoking, gender, antipsychotic medication, and dietary factors did not explain the bimodal distribution.Conclusions: Red blood cell PUFA were bimodally distributed among acutely ill patients with schizophrenia and schizoaffective disorder. Endogenous deficiencies of redox regulation or synthesis of long-chain PUFA in the low PUFA group may explain our findings.