Contractions of the isolated uterus stimulated by epidermal growth factor
Contractions of the isolated uterus stimulated by epidermal growth factor
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表皮生长因子刺激离体子宫的收缩
DOI：
10.1096/fasebj.1.3.3497834
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
G. Stancel
中科院分区：
文献类型：
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作者：
R. Gardner;R. Lingham;G. Stancel
表皮生长因子(EGF)在取自未成熟和成年大鼠的组织中产生子宫收缩。EGF既能增加静息音调，又能促进节律性收缩，这种作用可通过抗EGF抗体的治疗而消除。当EGF浓度为3.5 nm时，观察到该响应的ED50。EGF的这种体外效应需要在去除子宫组织之前用雌二醇体内处理动物24小时。雌二醇的这种作用似乎并不完全是由于组织中EGF受体的诱导。这些结果证明了EGF的一种新的活性，并表明了这种肽生长因子的一种以前未知的功能。-Gardner，R.M.；Lingham，R.B.；Stancel，G.M.由表皮生长因子刺激的离体子宫的收缩。FASEB J.1：224-228；1987。
Epidermal growth factor (EGF) produces uterine contractions in tissues removed from immature and adult rats. EGF produces both an increase in resting tone and the development of rhythmic contractions, and this effect is abolished by treatment with antibodies against EGF. The ED50 for this response is observed at an EGF concentration of 3.5 nm. This in vitro effect of EGF requires treatment of the animals in vivo with estradiol for 24 h before removal of uterine tissue. This effect of estradiol does not appear to be due solely to an induction of tissue EGF receptors. These results demonstrate a new activity of EGF and suggest a previously unrecognized function for this peptide growth factor.— Gardner, R. M.; Lingham, R. B.; Stancel, G. M. Contractions of the isolated uterus stimulated by epidermal growth factor. FASEB J. 1: 224‐228; 1987.
表皮生长因子和佛波酯对人骨肉瘤细胞的作用。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Shupnik,MA;TashjianJr,AH
通讯作者：
TashjianJr,AH