Measurement of characteristic prompt gamma rays emitted from oxygen and carbon in tissue-equivalent samples during proton beam irradiation.
Measurement of characteristic prompt gamma rays emitted from oxygen and carbon in tissue-equivalent samples during proton beam irradiation.
复制标题
DOI：
10.1088/0031-9155/58/17/5821
复制
发表时间：
2013-09-07
影响因子：
3.5
通讯作者：
Beddar S
中科院分区：
文献类型：
--
作者：
Polf JC;Panthi R;Mackin DS;McCleskey M;Saastamoinen A;Roeder BT;Beddar S
这项工作的目的是表征如何迅速伽马（PG）发射从组织的变化作为碳和氧浓度的函数，并评估确定元素浓度的可行性，在组织中的质子束照射。在这项研究中，四个组织等效的水蔗糖样品具有不同的密度和浓度的碳，氢，和氧用48兆电子伏的质子笔束照射。使用高纯度锗检测器测量从每个样品发射的PG光谱，并且还测量检测器的绝对检测效率、平均束流和递送剂量分布。从12C（4.44 MeV）和16O（6.13 MeV）每入射质子和每格雷的吸收剂量的总PG排放的变化，其特征在于作为碳和氧浓度的函数在样品中。4.44兆电子伏PG发射每入射质子的强度被认为是几乎恒定的所有样品，无论其碳浓度。然而，我们发现，6.13兆电子伏PG排放量线性增加的样品中照射的氧气的总量（克）。从测量的PG数据，我们确定了1.64 × 107氧PG发射每克氧气照射每戈瑞的吸收剂量提供了一个48 MeV的质子束。这些结果表明，6.13 MeV的PG发射从16 O与质子束照射的组织中的氧浓度成正比，表明它是可能的，以确定组织内的氧浓度与质子束照射通过测量16 O PG发射。
The purpose of this work was to characterize how prompt gamma (PG) emission from tissue changes as a function of carbon and oxygen concentration, and to assess the feasibility of determining elemental concentration in tissues irradiated with proton beams. For this study, four tissue-equivalent water-sucrose samples with differing densities and concentrations of carbon, hydrogen, and oxygen were irradiated with a 48 MeV proton pencil beam. The PG spectrum emitted from each sample was measured using a high-purity germanium detector, and the absolute detection efficiency of the detector, average beam current, and delivered dose distribution were also measured. Changes to the total PG emission from 12C (4.44 MeV) and 16O (6.13 MeV) per incident proton and per Gray of absorbed dose were characterized as a function of carbon and oxygen concentration in the sample. The intensity of the 4.44 MeV PG emission per incident proton was found to be nearly constant for all samples regardless of their carbon concentration. However, we found that the 6.13 MeV PG emission increased linearly with the total amount (in grams) of oxygen irradiated in the sample. From the measured PG data, we determined that 1.64 × 107 oxygen PGs were emitted per gram of oxygen irradiated per Gray of absorbed dose delivered with a 48 MeV proton beam. These results indicate that the 6.13 MeV PG emission from 16O is proportional to the concentration of oxygen in tissue irradiated with proton beams, showing that it is possible to determine the concentration of oxygen within tissues irradiated with proton beams by measuring 16O PG emission.
登录
查看更多内容
DOI：
10.1016/j.ijrobp.2006.10.007
发表时间：
2007-02-01
影响因子：
7
作者：
Beddar, A. Sam;Kainz, Kristofer;Krishnan, Sunil
通讯作者：
Krishnan, Sunil
影响因子：
3.5
作者：
Bom, Victor;Joulaeizadeh, Leila;Beekman, Freek
通讯作者：
Beekman, Freek
影响因子：
8.7
作者：
Kozlovsky, B;Murphy, RJ;Ramaty, R
通讯作者：
Ramaty, R
影响因子：
3.8
作者：
Min, Chul Hee;Lee, Han Rim;Lee, Se Byeong
通讯作者：
Lee, Se Byeong
影响因子：
3.5
作者：
Butterworth, Karl T.;McGarry, Conor K.;Prise, Kevin M.
通讯作者：
Prise, Kevin M.