A case of a progressive multifocal leukoencephalopathy patient with four different JC virus transcriptional control region rearrangements in cerebrospinal fluid, blood, serum, and urine
A case of a progressive multifocal leukoencephalopathy patient with four different JC virus transcriptional control region rearrangements in cerebrospinal fluid, blood, serum, and urine
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DOI：
10.1080/13550280590900382
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发表时间：
2005-02-01
影响因子：
3.2
通讯作者：
Ferrante, P
中科院分区：
文献类型：
--
作者：
Delbue, S;Sotgiu, G;Ferrante, P
JC 病毒 (JCV) 是进行性多灶性白质脑病 (PML) 的病原体，PML 是一种致命的中枢神经系统 (CNS) 脱髓鞘疾病。在获得性免疫缺陷综合症（艾滋病）流行期间，它是导致高达8%的艾滋病患者死亡的原因。 JCV 的基因组结构，特别是转录控制区 (TCR)（一种调节性非编码区）的高度变异性是众所周知的。鉴于 TCR 在 JCV 的病毒复制中发挥核心作用，因此也怀疑其在确定病毒的向神经性和致病能力中发挥着至关重要的作用。在此，作者描述了一个对高效抗逆转录病毒疗法 (HAART) 治疗没有反应的 PML 病例。尿液、外周血细胞、血清和脑脊液 (CSF) 样本中同时存在具有四种不同 TCR 结构的 JCV 菌株。这些数据证实了原型 TCR 的存在仅限于尿液，同时也表明重排的程度从外周血到脑脊液有所不同并有所增加。
JC virus (JCV) is the etiological agent of progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease of the central nervous system (CNS). During the acquired immunodeficiency syndrome (AIDS) epidemic, it was the cause of the death in up to 8% of AIDS patients. The genomic organization of JCV and, in particular, the hypervariability of the transcriptional control region (TCR), a regulatory noncoding region, are well known. Given that the TCR plays a central role in the viral replication of JCV, a crucial role in the determination of the neurotropism and in the pathogenic capabilities of the virus is also suspected. Here the authors describe a case of PML that did not respond to highly active antiretroviral therapy (HAART) therapy. There was a simultaneous presence of JCV strains with four different TCR structures in urine, peripheral blood cells, serum, and cerebrospinal fluid (CSF) samples. These data confirmed that the presence of the archetype TCR is restricted to urine, while also suggesting that the degree of the rearrangement varies and increases from the peripheral blood to CSF.