Vitamin D and breast cancer risk
Vitamin D and breast cancer risk
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DOI：
10.1016/j.beem.2008.08.002
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发表时间：
2008-08-01
影响因子：
7.4
通讯作者：
Colston, Kay W.
中科院分区：
文献类型：
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作者：
Colston, Kay W.
除了维持骨骼的重要作用外，越来越多的证据表明，维生素D对身体其他系统也有影响，而最佳健康状态可能需要充足的维生素D供应。维生素D可以从饮食中获得，也可以通过暴露在阳光下的皮肤合成。一些流行病学研究表明，缺乏维生素D和减少太阳中波紫外线辐射会增加患某些癌症的风险，包括乳腺癌。维生素D的活性代谢物1,25-二羟基维生素D-3主要在肾脏中合成，并且在实验室研究中显示对乳腺癌细胞具有强大的抗增殖作用。正常和肿瘤乳腺组织都含有维生素D受体，基因消融研究表明，这种受体与正常乳腺发育有关。在维生素D受体基因中已经发现了几种多态性，在一些研究中，这些多态性与乳腺癌的风险有关。乳腺组织中1,25-二羟基维生素D-3的局部合成可能有助于维持正常的细胞功能，这可能在维生素D缺乏时受损。
In addition to its important role in the maintenance of the skeleton, there is mounting evidence that vitamin D has effects on other body systems, and that adequate supplies of vitamin D are likely to be required for optimal health. Vitamin D is obtained both from dietary sources and from cutaneous synthesis with exposure to sunlight. Some epidemiological studies have indicated that vitamin D deficiency and decreased exposure to solar UVB radiation increase the risk of some cancers, including breast cancer. The active metabolite of vitamin D, 1,25-dihydroxy-vitamin D-3, is synthesized primarily in the kidney, and has been shown in laboratory studies to have potent anti-proliferative effects on breast cancer cells. Normal and neoplastic breast tissues contain the vitamin D receptor, and gene ablation studies have implicated the receptor in normal breast development. Several polymorphisms have been identified in the vitamin D receptor gene, and these have been associated with risk of breast cancer in some studies. Local synthesis of 1,25-dihydroxyvitamin D-3 in breast tissue may contribute to maintenance of normal cell function, which could be impaired in vitamin D deficiency.