Robust selection of sensory organ precursors by the Notch-Delta pathway
Robust selection of sensory organ precursors by the Notch-Delta pathway
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DOI：
10.1016/j.ceb.2011.09.005
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发表时间：
2011-12-01
影响因子：
7.5
通讯作者：
Barkai, Naama
中科院分区：
文献类型：
--
作者：
Barad, Omer;Hornstein, Eran;Barkai, Naama
多细胞生物的模式化对于环境、遗传或随机波动是稳健的。数学建模有助于确定支持这种鲁棒性的机制。侧抑制的原理，即分化细胞抑制其邻居采用相同的命运，经常用于从一群等能细胞中选择单个细胞。例如，果蝇中的感觉器官前体（SOP）通过激活Notch Delta途径实现侧向抑制。我们讨论的参数影响的错误率在这个过程中，和机制（抑制性顺式之间的相互作用Notch和三角洲）预测，以减少这种错误。
The patterning of multicellular organisms is robust to environmental, genetic, or stochastic fluctuations. Mathematical modeling is instrumental in identifying mechanisms supporting this robustness. The principle of lateral inhibition, whereby a differentiating cell inhibits its neighbors from adopting the same fate, is frequently used for selecting a single cell out of a cluster of equipotent cells. For example, Sensory Organ Precursors (SOP) in the fruit-fly Drosophila implement lateral inhibition by activating the Notch Delta pathway. We discuss parameters affecting the rate of errors in this process, and the mechanism (inhibitory cis interaction between Notch and Delta) predicted to reduce this error.