Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland.
Fetal antigen 1 (FA1) in the adult rat adrenal gland, ovary and pituitary gland.
复制标题
成年大鼠肾上腺、卵巢和垂体中的胎儿抗原 1 (FA1)。
作者：
G. P. Hedlund;H. Carlsson;E. Shieck;I. Nilsson;C. Lundblad;S. Arons;A. Iversen;C. Looman;H. Jensen;J. Hau
胎儿抗原1（FA 1）是一种循环糖蛋白，含有6个表皮生长因子（EGF）样重复序列。FA 1较大的膜结合前体由称为人δ样（dlk）或人肾上腺特异性cDNA（pG 2）的cDNA定义。在啮齿类动物中，FA 1也被称为前脂肪细胞因子1（Pref-1）和肾小球特异性因子（ZOG）。FA 1在胎儿组织中大量表达，但在成年生物体的成熟细胞中，该蛋白质的组织存在似乎仅限于神经内分泌组织。本研究表明FA 1定位在成年雌性大鼠的内分泌组织中，该蛋白质被发现存在于肾上腺皮质的髓质和肾小球中，在腺垂体的远侧部，以及在卵巢颗粒黄体细胞中。在胰腺中未发现染色，这与在人类中所描述的相反。
Fetal antigen 1 (FA1) is a circulating glycoprotein containing six epidermal growth factor (EGF)-like repeats. FA1's larger membrane-bound precursor is defined by the cDNAs referred to as either human delta-like (dlk) or human adrenal specific cDNA, pG2. In rodents FA1 has also been studied under the names of preadipocyte factor 1 (Pref-1), and zona glomerulosa-specific factor (ZOG). FA1 is abundantly expressed in fetal tissues, but in the mature cells of the adult organism the tissue presence of the protein seems to be restricted to neuroendocrine tissues. The present study demonstrates FA1 localisation in endocrine tissues of the adult female rat in which the protein was found present in the medulla and the zona glomerulosa of the cortex of the adrenal glands, in the pars distalis of the adenohypophysis, and in the ovarian granulosa lutein cells. No staining was found in the pancreas, which is in contrast to what has been described in the human.