RELIEF OF EPILEPSY BY RADIOSURGERY OF CEREBRAL ARTERIOVENOUS-MALFORMATIONS
RELIEF OF EPILEPSY BY RADIOSURGERY OF CEREBRAL ARTERIOVENOUS-MALFORMATIONS
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DOI：
10.1159/000099532
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发表时间：
1989-01-01
影响因子：
1.7
通讯作者：
PAK, VA
中科院分区：
文献类型：
--
作者：
HEIKKINEN, ER;KONNOV, B;PAK, VA
129例无法手术的脑动静脉畸形（AVM）患者接受立体定向质子束照射治疗。 29 名患者 (22.5%) 在治疗前出现症状性癫痫。放射外科治疗使 16 名患者的癫痫发作停止，症状明显缓解，持续无癫痫发作的随访期为 2 至 8 年（平均 4.5 年）。在任何情况下，放射外科手术都不会导致癫痫恶化。对癫痫的积极作用并不严格取决于血管造影结果，这表明电离辐射本身可以抑制 AVM 周围的癫痫活动。
129 patients with inoperable cerebral arteriovenous malformations (AVM) were treated by stereotactic proton beam irradiation. Symptomatic epilepsy was present in 29 patients (22.5%) before the treatment. It was markedly relieved by the radiosurgery leading to cessation of the seizures in 16 patients, the persisting seizure-free follow-up period ranging from 2 to 8 years (mean 4.5 years). In no case was the epilepsy worsened by radiosurgery. The positive effect on epilepsy was not strictly dependent on the angiographic result, suggesting that the ionizing radiation by itself could lead to inhibition of epileptic activity around the AVM.