Biomarkers in tumor angiogenesis and anti-angiogenic therapy.
Biomarkers in tumor angiogenesis and anti-angiogenic therapy.
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DOI：
10.3390/ijms12107077
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发表时间：
2011
影响因子：
5.6
通讯作者：
Medinger M
中科院分区：
文献类型：
--
作者：
Pircher A;Hilbe W;Heidegger I;Drevs J;Tichelli A;Medinger M
肿瘤血管生成在肿瘤生长和肿瘤进展中起着重要作用，并受到血管生成和抗血管生成细胞因子平衡的调节。其中VEGF（血管内皮生长因子）及其通过其受体的信号传导是至关重要的相关性。通过单克隆抗体或小分子（激酶抑制剂）抑制VEGF信号传导已经成功地建立用于治疗不同的癌症实体，并且多种新药正在临床试验中进行测试。然而，并非所有患者都可能对这些疗法有反应，但迄今为止还没有可靠的生物标志物可用于预测治疗反应。许多研究在其研究方案中整合了生物标志物项目，因此已经确定了几种潜在的生物标志物，目前正在前瞻性随机研究中进行临床研究。本综述旨在概述所描述的潜在生物标志物以及不同的成像技术，如超声和磁共振成像，可以表明抗血管生成治疗的益处，耐药性和毒性。
Tumor angiogenesis has been identified to play a critical role in tumor growth and tumor progression, and is regulated by a balance of angiogenic and anti-angiogenic cytokines. Among them VEGF (vascular endothelial growth factor) and its signaling through its receptors are of crucial relevance. Inhibition of VEGF signaling by monoclonal antibodies or small molecules (kinase inhibitors) has already been successfully established for the treatment of different cancer entities and multiple new drugs are being tested in clinical trials. However not all patients are likely to respond to these therapies, but to date there are no reliable biomarkers available to predict therapy response. Many studies integrated biomarker programs in their study protocols, thus several potential biomarkers have been identified which are currently under clinical investigation in prospective randomized studies. This review intends to give an overview of the described potential biomarkers as well as different imaging techniques such as ultrasound and magnetic resonance imaging that can indicate benefit, resistance and toxicity to anti-angiogenic therapies.
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