Inflammatory stromal reaction correlates with lymphatic microvessel density in early-stage cervival cancer.
Inflammatory stromal reaction correlates with lymphatic microvessel density in early-stage cervival cancer.
复制标题
炎症基质反应与早期宫颈癌的淋巴微血管密度相关。
作者：
S. Schoppmann;M. Schindl;S. Breiteneder;A. Soleima;G. Breitenecker;B. Karner;P. Birner
背景
在早期宫颈癌中，高淋巴管密度（LMVD）表明预后良好。这一意外发现被认为是局部免疫反应的影响，尽管没有数据支持这一论点。
材料和方法
采用免疫组化法检测85例pT1b期宫颈癌组织中淋巴管内皮细胞标志物podoplanin的表达，并对LMVD和淋巴管浸润（LVI）进行评估。局部免疫反应，明显的炎症基质反应（ISR），确定在H& E染色的载玻片和评级从1级（无或弱）到3级（强）
结果
发现LMVD和ISR具有良好的相关性（p=0.002）。虽然发现LMVD和LVI的存在之间有很强的相关性（p<0.001），但没有观察到LMVD和盆腔淋巴结受累之间的相关性（p=0.732）。ISR表明患者预后良好（p=0.0247，对数秩检验）。
结论
我们的研究结果表明，ISR可能在诱导早期宫颈癌淋巴管生成中发挥作用。
BACKGROUND
In early-stage cervical cancer, high lymphatic microvessel density (LMVD) indicates favorable prognosis. This unexpected finding was thought to be an effect of local immunological response, although no data supported this thesis.
MATERIALS AND METHODS
LMVD and lymphovascular invasion (LVI) were assessed in 85 specimens of cervical cancer stage pT1b by immunostaining for podoplanin, a marker for lymphatic endothelia. Local immunological response, evident by inflammatory stromal reaction (ISR), was determined in H&E-stained slides and rated from grade 1 (absent or weak) to 3 (strong)
RESULTS
A good correlation of LMVD and ISR was found (p=0.002). While a strong correlation between LMVD and the presence of LVI was found (p<0.001), no association between LMVD and pelvic lymph node involvement (p=0.732) was observed. ISR indicated favourable prognosis of patients (p=0.0247, log-rank test).
CONCLUSION
Our findings suggest that ISR might play a role in the induction of lymphangiogenesis in early stage cervical cancer.