Decreased social interactions in monkeys after unilateral blockade of GABAA receptors in the basolateral amygdala
Decreased social interactions in monkeys after unilateral blockade of GABAA receptors in the basolateral amygdala
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DOI：
10.1111/j.1749-6632.2003.tb07122.x
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Gale, K
中科院分区：
文献类型：
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作者：
Malkova, L;Barrow, KV;Gale, K
内侧颞叶或杏仁核的双侧消融已被证明可引起社会情感行为的深刻变化，包括亲和行为减少、攻击性减少、驯服性增加以及无法维持在社会群体中的主导地位（有关综述，请参阅 Kling 和 Brothers1）。这些在成年猴子中的原始结果已在婴儿和幼年猴子中得到复制，表明杏仁核损伤的社会情感影响至少在未成熟的动物中同样明显。 2, 3 这些研究都是在测试开始前已经相互熟悉的动物组中进行的。相比之下，杏仁核损伤对不熟悉的动物对的社会互动的影响与对熟悉的动物的社会互动的影响不同，因为不熟悉的动物对的社会接触往往会增加。 4 因此，杏仁核功能障碍引起的特定行为干扰取决于社会背景。为了充分探索杏仁核失活的年龄依赖性和环境依赖性影响，局部杏仁核内药物应用提供了一种理想的实验方法。我们一直有兴趣评估药物引起的杏仁核短暂功能障碍对不同年龄和各种环境下的猴子行为的影响。我们的一般假设是，在关键发育时期杏仁核内的神经化学失衡可能会对社会情绪行为产生长期影响。在这里，我们评估了杏仁核基底外侧分区（BLA）内 GABAA 受体的可逆阻断对幼猴社交互动的影响。两只雄性和两只雌性辫尾猕猴（Macaca nemestrina），1V 岁，成对录像（全部由
Bilateral ablation of the medial temporal lobes or the amygdala alone has been shown to induce profound changes in socioemotional behavior, including a decrease in affiliative behavior, a decrease in aggression, an increase in tameness, and an inability to maintain dominance in a social group (for a review, see Kling and Brothers1). These original results in adult monkeys have been replicated in infant and juvenile monkeys, indicating that the socioemotional impact of the amygdala lesions is at least as pronounced in immature animals. 2, 3 These studies were all performed in groups of animals that had been familiarized with one another prior to the onset of testing. In contrast, the effects of the amygdala lesions on social interactions in unfamiliar pairs of animals are distinct from those seen in familiar pairs in that the social contact of the unfamiliar pairs tends to increase. 4 Thus, the specific behavioral disruption caused by amygdala dysfunction is dependent upon social context. To adequately explore the age-dependent and context-dependent effects of amygdala inactivation, the use of focal intra-amygdala drug application provides an ideal experimental approach.We have been interested in evaluating the impact of drug-induced transient dysfunction of the amygdala on behavior of monkeys of different ages and in a variety of settings. It is our general hypothesis that a neurochemical imbalance within the amygdala during a critical developmental period may have long-term consequences for socioemotional behavior. Here we evaluated the effects of the reversible blockade of GABAA receptors within the basolateral subdivision of the amygdala (BLA) on social interactions in juvenile monkeys. Two male and two female pigtailed macaques (Macaca nemestrina), 1V years old, were videotaped in dyads (all com-