Synthesis and antifungal activity of novel bis(dithiocarbamate) derivatives of glycerol
Synthesis and antifungal activity of novel bis(dithiocarbamate) derivatives of glycerol
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DOI：
10.1021/jf950751y
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发表时间：
1996-09-01
影响因子：
6.1
通讯作者：
Simon, H
中科院分区：
文献类型：
--
作者：
Len, C;BoulogneMerlot, AS;Simon, H
通过二硫代氨基甲酸盐与1，3-二氯-1，3-二脱氧甘油反应，以30-95%的产率获得了三种甘油的双（二硫代氨基甲酸酯）衍生物。以芸苔链格孢菌（Alternaria brassicae）、油菜假尾孢菌（Pseudocercosporella herpoderides）、颖壳针孢菌（Septoria nodorum）和肉桂疫霉（Phytophtora cinnamomi）为供试菌，对新化合物进行了体外抗真菌活性评价。一些化合物显示出比商业杀真菌剂更大的活性。双（N，N-二乙基二硫氨甲酰）-1，3-双脱氧甘油（4）在田间试验中对A.芸苔属。
Three bis(dithiocarbamate) derivatives of glycerol were obtained in 30-95% yields by reaction of a dithiocarbamic acid salt with 1,3-dichloro-1,3-dideoxyglycerol. The in vitro antifungal activity of the new compounds was evaluated against Alternaria brassicae, Pseudocercosporella herpotrichoides, Septoria nodorum, and Phytophtora cinnamomi. Some of the compounds displayed greater activity than commercial fungicides. Bis(N,N-diethyldithiacarbamoyl)-1,3-dideoxyglycerol (4) was found to maintain its pesticidal activity up to 24 days in open field tests against A. brassicae.