Cell-mediated cytotoxicity in isogeneic ginbuna crucian carp
Cell-mediated cytotoxicity in isogeneic ginbuna crucian carp
复制标题
同基因银鲫细胞介导的细胞毒性
DOI：
10.1006/fsim.1998.0191
复制
发表时间：
1999
影响因子：
4.7
通讯作者：
N. Okamoto
中科院分区：
文献类型：
--
作者：
T. Nakanishi;N. Okamoto
摘要本文综述了利用克隆三倍体ginbuna研究鱼类细胞毒性的最新进展，并讨论了该物种作为研究鱼类免疫学模型的良好潜力。移植物抗宿主反应（GVHR）随后是体外细胞介导的对异体红细胞和细胞系的细胞毒性被描述为特异性细胞毒性活性。用银麻获得的体内和体外细胞介导的细胞毒性的特点是，需要对效应细胞供体反复致敏以诱导细胞毒性，杀死异体受体或细胞，但效应细胞不会杀死同种异体靶细胞，并且缺乏ADCC的参与。这些结果表明，银麻的细胞毒性是由同种异体反应性细胞毒性T细胞介导的，而不是非特异性细胞毒性细胞。银麻中性粒细胞的自发细胞毒活性也与NK细胞对人白血病细胞的活性和对同基因红细胞的自发杀伤有关。
Abstract This review describes recent studies on cell-mediated cytotoxicity of fish using clonal triploid ginbuna and discusses the excellent potential of this species as a model for studying fish immunology. Graft-versus-host reaction (GVHR) followed by in vitro cell-mediated cytotoxicity against allogeneic erythrocytes and cell lines are described as specific cytotoxic activity in ginbuna. In vivo and in vitro cell-mediated cytotoxicity obtained with ginbuna are characterised in terms of the requirement for repeated sensitisation of effector cell donors to induce cytotoxicity, killing of allogeneic recipients or cells but not isogeneic targets by effector cells, and the lack of involvement of ADCC. These results suggest that cytotoxicity in ginbuna is mediated by allo-reactive cytotoxic T cells rather than non-specific cytotoxic cells. Spontaneous cytotoxic activity of ginbuna neutrophils is also described with NK activity against human leukemic cells and spontaneous killing of isogeneic erythrocytes.
混合白细胞培养物中斑点叉尾鮰外周血白细胞产生的细胞毒活性。
DOI：
10.1006/cimm.1997.1106
发表时间：
1997
期刊：
Cellular immunology.
影响因子：
--
作者：
Stuge,TB;Yoshida,SH;Chinchar,VG;Miller,NW;Clem,LW
通讯作者：
Clem,LW
将移植物抗宿主病与同种异体 T 细胞的移植物抗白血病效应分开：IL-2 的潜在作用。
影响因子：
4.8
作者：
Sykes,M
通讯作者：
Sykes,M
淋巴细胞异质性的系统发育：斑点叉尾鮰外周血白细胞针对同种异体靶标的细胞毒活性。
影响因子：
2.9
作者：
Yoshida,SH;Stuge,TB;Miller,NW;Clem,LW
通讯作者：
Clem,LW