Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury.
Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury.
复制标题
康复：脊髓损伤后神经源性骨质流失。
DOI：
10.3390/biomedicines11092581
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发表时间：
2023-09-20
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
骨质疏松症是一种常见的骨骼疾病，由于骨折的风险增加，会严重限制一个人完成日常任务的能力，降低生活质量。脊髓损伤（SCI）也可导致骨质疏松症和肌肉减少症。大多数人由于年龄增长而经历肌肉减少症和骨质疏松症;然而，SCI患者由于神经原性因素，肌肉骨骼废用和细胞/分子事件而经历更快和更虚弱的肌肉和骨丢失水平。因此，保护和维持SCI后的骨量对于降低脆弱SCI人群的脆性和骨折风险至关重要。最近的研究提供了一个更好的理解的病理生理学和危险因素有关的肌肉骨骼损失后SCI。药理学和非药理学疗法也提供了减少或消除SCI后神经源性骨丢失。这篇综述文章将讨论SCI后肌肉和骨丢失的病理生理学和危险因素，包括可能导致SCI后肌肉和骨丢失的机制。本综述还将重点介绍目前和未来减少或消除SCI后神经源性骨丢失的药物和非药物治疗。
Osteoporosis is a common skeletal disorder which can severely limit one’s ability to complete daily tasks due to the increased risk of bone fractures, reducing quality of life. Spinal cord injury (SCI) can also result in osteoporosis and sarcopenia. Most individuals experience sarcopenia and osteoporosis due to advancing age; however, individuals with SCI experience more rapid and debilitating levels of muscle and bone loss due to neurogenic factors, musculoskeletal disuse, and cellular/molecular events. Thus, preserving and maintaining bone mass after SCI is crucial to decreasing the risk of fragility and fracture in vulnerable SCI populations. Recent studies have provided an improved understanding of the pathophysiology and risk factors related to musculoskeletal loss after SCI. Pharmacological and non-pharmacological therapies have also provided for the reduction in or elimination of neurogenic bone loss after SCI. This review article will discuss the pathophysiology and risk factors of muscle and bone loss after SCI, including the mechanisms that may lead to muscle and bone loss after SCI. This review will also focus on current and future pharmacological and non-pharmacological therapies for reducing or eliminating neurogenic bone loss following SCI.
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影响因子：
1.9
作者：
Bergmann P;Body JJ;Boonen S;Boutsen Y;Devogelaer JP;Goemaere S;Kaufman J;Reginster JY;Rozenberg S
通讯作者：
Rozenberg S
影响因子：
2.2
作者：
Alazzam, Ahmad M.;Goldsmith, Jacob A.;Gorgey, Ashraf S.
通讯作者：
Gorgey, Ashraf S.
影响因子：
6.2
作者：
Carbone, Laura D.;Chin, Amy S.;Weaver, Frances
通讯作者：
Weaver, Frances
影响因子：
4
作者：
Cirnigliaro, Christopher M. M.;La Fountaine, Michael F. F.;Bauman, William A. A.
通讯作者：
Bauman, William A. A.
影响因子：
3.6
作者：
Liu FL;Chen CL;Lee CC;Wu CC;Hsu TH;Tsai CY;Huang HS;Chang DM
通讯作者：
Chang DM