Native Renal Cysts and Dialysis Duration Are Risk Factors for Renal Cell Carcinoma in Renal Transplant Recipients
Native Renal Cysts and Dialysis Duration Are Risk Factors for Renal Cell Carcinoma in Renal Transplant Recipients
复制标题
DOI：
10.1111/j.1600-6143.2010.03303.x
复制
发表时间：
2011-01-01
影响因子：
8.8
通讯作者：
Vathsala, A.
中科院分区：
文献类型：
--
作者：
Goh, A.;Vathsala, A.
尿路癌是肾移植受体（RTX）中第三大常见的癌症。这项研究研究了透析持续时间和天然肾囊肿（NRC）对1995年至2007年7月1036 RTX随访的肾细胞癌（RCC）发生的影响。每5年或2年肾囊肿。基于NRC的存在和开发时间，将RTX分组为NO（No-NRC），New NRC（New-NRC），PREEXISTING（PRE-NRC）和时间差异NRC（TI-NRC）的RTX。在适当的治疗后，在移植后中位数中位数为5。8年，在移植后中位数为5。8年，在移植后的中位数为5.8年，患者5年的移植物和患者存活率分别为5年，患有5年的移植物和患者存活率分别诊断为RCC。 RCC仅在NRC和Ti-NRC之前发生，他们的透析持续时间明显长于NO-或NOW-NRC（6.7 +/- 3.9和3.3 +/- 3.2 +/- 3.2 vs. 2.7 +/- 3.1和2.6 +/- 2.6 +/- 2.4年， 分别）。这些结果表明，NRC和透析持续时间增加是RCC移植后的危险因素。由于RCC的早期治疗可提供出色的结果，因此建议在移植的一个月内进行常规的超声检查，然后对于没有囊肿的人每5年，对于患有囊肿的人每2年进行每5年，建议早日检测RCC。
Urinary tract cancers are the third most common cancers in renal transplant recipients (RTX). This study examined the impact of dialysis duration and native renal cyst(s) (NRC) on renal cell carcinoma (RCC) occurrence among 1036 RTX followed-up from 1995 to July 2007. Abdominal ultrasonography was planned within 1-month of transplant, then every 5 years, or 2 years if renal cysts developed. Based on presence and time of development of NRC, RTX were grouped into those with no (No-NRC), new (New-NRC), preexisting (Pre-NRC) and time-indeterminate NRC (TI-NRC). Ten asymptomatic RTX were diagnosed with RCC at a median of 5.8 years posttransplant and had 5-year graft and patient survivals of 90% and 100%, respectively, following appropriate therapy. RCC occurred only in Pre-NRC and TI-NRC who had significantly longer dialysis duration than No- or New-NRC (6.7 +/- 3.9 and 3.3 +/- 3.2 vs. 2.7 +/- 3.1 and 2.6 +/- 2.4 years, respectively). These results suggest that NRC and increased dialysis duration are risk factors for RCC posttransplant. Since early treatment of RCC gives excellent outcomes, regular ultrasonography performed within a month of transplantation, then every 5 years for those without cysts and every 2 years for those with cysts for early detection of RCC is recommended.