Microencapsulation peptide and protein drugs delivery system
Microencapsulation peptide and protein drugs delivery system
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DOI：
10.1016/j.colsurfb.2004.10.032
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发表时间：
2005-03-25
影响因子：
5.8
通讯作者：
Zhao, HW
中科院分区：
文献类型：
--
作者：
Dai, CY;Wang, BC;Zhao, HW
肽类和蛋白质类药物给药系统（DDS）的设计方法很多。由于其相对较大的尺寸，它们具有低的透皮生物利用度。在蛋白质的全身递送中，生物可降解材料作为胃肠外贮库制剂占据重要的位置，因为几个方面如保护敏感蛋白质免于降解、延长或修饰释放、脉冲释放模式。开发控释蛋白质注射剂的主要目的是避免常规的侵入性剂量，这反过来又提供了患者的依从性、舒适性以及对血液水平的控制。本文综述了微胶囊作为蛋白质递送系统在蛋白质递送领域的突出贡献，并介绍了不同的蛋白质递送方法。然后讨论了这些进展如何可能被应用于解决所面临的挑战，微胶囊的发展，蛋白质药物的可控传输。(c)2004年由Elsevier B.V.出版
Many methods were used to devise peptide and protein drugs delivery system (DDS). Because of their relatively large size, they have low transdermal bioavailabilities. In systemic delivery of proteins, biodegradable material as parenteral depot formulation occupy an important place because of several aspects like protection of sensitive proteins from degradation, prolonged or modified release, pulsatile release patterns. The main objective in developing controlled release protein injectables is avoidance of regular invasive doses which in turn provide patient compliance, comfort as well as control over blood levels. This review article presents the outstanding contributions in field of microencapsulation as protein delivery systems and different approaches of protein delivery are described. Then discusses how these advances may be applied to resolve the challenges face the development of microcapsule for the controllable delivery of protein drugs. (c) 2004 Published by Elsevier B.V.