Microperfusion-Induced Elevation of ADC Is Suppressed After Contrast in Breast Carcinoma
Microperfusion-Induced Elevation of ADC Is Suppressed After Contrast in Breast Carcinoma
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DOI：
10.1002/jmri.21743
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发表时间：
2009-05-01
影响因子：
4.4
通讯作者：
Nishimura, Tsunehiko
中科院分区：
文献类型：
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作者：
Yuen, Sachiko;Yamada, Kei;Nishimura, Tsunehiko
目的：为探讨钆喷酸葡胺（Gd）-DTPA对乳腺癌表观扩散系数（ADC）的影响，分析增强前后ADC值与增强程度的关系。在造影剂给药前和给药后测量其ADC。对比噪声比（CNR）的肿瘤进行了测量，在脂肪抑制三维T1加权图像在造影前，早期和后期对比阶段。结果：造影剂组ADC值较对照组明显降低（-23%，P = 0.01）。增强前ADC值相对较高的病变。（> 1.3 × 10（-3）mm（2）/sec; n = 12）显示ADC降低程度（平均34%）大于低ADC病变（
Purpose: To investigate the effect of gadolinium (Gd)-DTPA on the apparent diffusion coefficient (ADC) of breast carcinoma and to analyze the relationship between pre/post-contrast ADC and the degree of contrast enhancement.Materials and Methods: Nineteen histopathologically confirmed breast carcinomas (mean size = 22 mm) were analyzcd. Their ADCs before and after contrast administration were measured. The con trast-to-noise ratios (CNRs) of the tumors were measured on fat-suppressed 3D T1-weighted images in precontrast, early, and late postcontrast phases. These results were correlated with the measured ADC values.Results: A significant decrease in the measured ADC was noted after contrast administration (-23%, P = 0.01). Lesions with relatively high ADC before contrast. (> 1.3 X 10(-3) mm(2)/sec; n = 12) demonstrated a larger degree of ADC reduction (mean 34%) than lesions with low ADC (