COMPARATIVE STUDY OF 4 METHODS OF DETERMINING ALKALINE PHOSPHATASE
COMPARATIVE STUDY OF 4 METHODS OF DETERMINING ALKALINE PHOSPHATASE
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DOI：
10.1056/nejm196406112702403
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发表时间：
1964-01-01
影响因子：
158.5
通讯作者：
ZAMCHECK, N
中科院分区：
文献类型：
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作者：
DEREN, JJ;WILLIAMS, LA;ZAMCHECK, N
对血清碱性磷酸酶的Bodansky、King-Armstrong、Bessey-Lowry和Klein测定系统进行了评价。根据前3种方法的双盲重复测定计算的测定的95%置信限范围为比所得值高50%至低33%。克莱因变异性较大，尤其是在低值时。前3种方法也在很宽的磷酸酶活性范围内彼此线性相关。当研究高碱性水平的血清时，Klein方法显示出下降。这4种方法在检测各种临床疾病时同样敏感。
The Bodansky, King-Armstrong, Bessey-Lowry and Klein assay systems for serum alkaline phosphatase were evaluated. The 95% confidence limit of the determination calculated from double-blind duplicate determinations for the first 3 methods ranged from 50% greater to 33% lower than the value obtained. The Klein variability was greater, especially at low values. The first 3 methods were also linearly related to each other over a wide range of phosphatase activity. The Klein method showed a falloff when serums with high alkaline levels were studied. The 4 methods were equally sensitive in detecting a wide variety of clinical diseases.