Choroidal Thickness is Increased following Restraint Stress in Rats
Choroidal Thickness is Increased following Restraint Stress in Rats
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DOI：
10.1080/02713683.2023.2171067
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发表时间：
2023-01-30
影响因子：
2
通讯作者：
Gomi, Fumi
中科院分区：
文献类型：
--
作者：
Maeda, Yuki;Takata, Masashi;Gomi, Fumi
目的中心性浆液性脉络膜视网膜病变是一种应激诱发的疾病，常表现为脉络膜肥厚；然而，压力和脉络膜之间的关系仍然不清楚。本研究的目的是利用光学相干断层扫描技术研究大鼠受到束缚应激时脉络膜是否增厚。方法对8周龄雄性F334/Jcl大鼠进行30分钟的束缚应激，采用光学相干断层扫描技术测量应激加载前后脉络膜厚度。此外，在压力负荷前后测量唾液皮质酮水平。结果压力负荷后脉络膜厚度从30.1+/-6.4μm显着增加到39.7+/-9.2μm(p=0.001)。第二天没有观察到明显的脉络膜增厚。唾液皮质酮浓度从应激负荷前的1575.3 +/- 1040.6 pg/mL增加到应激负荷后的6022.2 +/- 6742.6 pg/mL，但差异不显着(p = 0.10)。结论当大鼠受到束缚应激时，脉络膜厚度增加，支持了应激是粗脉络膜谱系疾病的原因之一的假设，如图所示由中心性浆液性脉络膜视网膜病变引起。
PurposeCentral serous chorioretinopathy is a stress-induced disease and often shows pachychoroid; however, the relationship between stress and choroid remains unlear. The purpose of this study was to investigate, using optical coherence tomography, whether the choroid thickens when rats are subjected to restraint stress.MethodsEight-week-old male F334/Jcl rats were subjected to 30 min of restraint stress, and choroidal thickness was measured before and after stress loading using optical coherence tomography. In addition, salivary corticosterone levels were measured before and after stress loading.ResultsChoroidal thickness was significantly increased from 30.1 +/- 6.4 mu m to 39.7 +/- 9.2 mu m just after stress loading (p = 0.001). Significant choroidal thickening was not observed on the next day. The salivary corticosterone concentration increased from 1575.3 +/- 1040.6 pg/mL before stress loading to 6022.2 +/- 6742.6 pg/mL after stress loading, but the difference was not significant (p = 0.10).ConclusionsChoroidal thickness increased when rats were subjected to restraint stress, supporting the hypothesis that stress is one of the causes of pachychoroid spectrum disease, as exemplified by central serous chorioretinopathy.