Effect and feasibility of the combination of branched chain amino acid and exercise therapy on muscle mass and echo intensity of muscle in orthopedic patients in a convalescent rehabilitation hospital: A crossover trial.
Effect and feasibility of the combination of branched chain amino acid and exercise therapy on muscle mass and echo intensity of muscle in orthopedic patients in a convalescent rehabilitation hospital: A crossover trial.
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DOI：
10.1002/hsr2.1316
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发表时间：
2023-06
影响因子：
2
通讯作者：
Kanzaki, Koji
中科院分区：
文献类型：
--
作者：
Ikeda, Takashi;Suzuki, Sadaoki;Aimoto, Kenji;Kamono, Arinori;Matsunaga, Yuki;Noguchi, Yu;Jinno, Tetsuya;Kanzaki, Koji
本研究旨在探讨营养支持结合运动干预对恢复期骨科患者肌肉和身体功能的可行性。我们采用交叉设计，在早期（1个月）和晚期（1个月）周期内每日给予营养支持联合运动干预，洗脱期为1周。早期组和晚期组每天进行2次运动干预，持续2个月。运动干预包括一组肌肉力量，伸展和身体活动练习，每次20分钟。运动后立即进行营养干预。摄入3.4 g支链氨基酸补充剂（BCAA）或1.2 g淀粉。我们测量了骨骼肌质量和肢体等长肌力，并进行了平衡测试。交叉后，BCAA和安慰剂组进行了比较。BCAA组的股直肌（RF）回声强度改善率显著较高。营养干预顺序的比较显示，只有当给予支链氨基酸时，两组的RF回波强度才有显著影响。这项研究的结果表明，提出的综合干预改善恢复期骨科患者的肌肉质量和质量。
This study examined the feasibility of nutritional support combined with exercise intervention for restoring muscle and physical functions in convalescent orthopedic patients. We used a crossover design in which nutritional support combined with exercise intervention was administered daily during the early (1 month) and late (1 month) cycles with a 1‐week washout period. The exercise intervention was performed twice daily for 2 months in the early and late groups. The exercise intervention consisted of one set of muscle strength, stretching, and physical activity exercises for 20 min each. Nutritional interventions were administered immediately after the exercise. A 3.4 g of branched‐chain amino acid supplements (BCAAs) or 1.2 g of starch was ingested. We measured the skeletal muscle mass and isometric muscle strength of the limbs and performed balance tests. After the crossover, the BCAA and Placebo groups were compared. The ratio of improvement in the echo intensity of the rectus femoris (RF) was significantly higher in the BCAA group. A comparison of the order of nutritional intervention showed a significant effect on the RF echo intensity in both groups only when BCAAs were administered. This study's results suggest that the proposed combined intervention improves muscle quality and mass in convalescent orthopedic patients.