Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus
Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus
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DOI：
10.1086/381504
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发表时间：
2004-02-15
影响因子：
6.4
通讯作者：
Gillison, ML
中科院分区：
文献类型：
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作者：
Kreimer, AR;Alberg, AJ;Gillison, ML
口腔人乳头瘤病毒(HPV)感染的患病率和危险因素尚不清楚，尽管有证据表明HPV在口腔癌中起病因学作用。对人类免疫缺陷病毒(HIV)血清阴性(n=396)和HIV血清阳性(n=190)成人口腔标本进行了HPVDNA检测。高危HPV感染出现在2.1%的扁桃体和6.3%的口腔含漱液样本中。在HIV血清阳性的个体中，口腔高危HPV感染的流行率更高(13.7%比4.5%；P<；.001)。在多元Logistic回归分析中，在HIV血清阴性的个体中，口腔HPV感染的几率随着年龄、男性和单纯疱疹病毒(HSV)-2血清阳性的增加，在HIV血清阳性的个体中，前一年有1个口腔性伴侣的CD4细胞计数(优势比，12.8；95%可信区间，3.1-52.7)增加。HPV 16型存在于大多数HPV相关的扁桃体癌中，是最普遍的高危口腔HPV感染。
The prevalence and risk factors for oral human papillomavirus (HPV) infection are unknown, despite evidence for an etiological role for HPV in oral cancers. Oral samples from human immunodeficiency virus (HIV)-seronegative (n = 396) and HIV-seropositive (n = 190) adults were tested for HPV DNA. High-risk HPV infections were present in 2.1% of tonsil and 6.3% of oral-rinse specimens. The prevalence of oral high-risk HPV infection was greater in HIV-seropositive individuals (13.7% vs. 4.5%; P < .001). In multiple logistic regression, odds of oral HPV infection increased with age, male sex, and herpes simplex virus (HSV)-2 seropositivity in HIV-seronegative individuals and with CD4 cell count 1 oral sex partner during the previous year (odds ratio, 12.8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection.