Association Between Stress and Coping with DNA Methylation of Blood Pressure-Related Genes Among African American Women.
Association Between Stress and Coping with DNA Methylation of Blood Pressure-Related Genes Among African American Women.
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DOI：
10.1177/2470547019879088
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Sun, Yan V
中科院分区：
文献类型：
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作者：
Brown, Kristen M;Hui, Qin;Sun, Yan V
背景技术背景：暴露于心理社会压力和就业的高努力应对策略已被确定为风险因素，可能部分解释高血压的患病率在非洲裔美国人。压力和应对可能影响高血压风险的一种生物学机制是通过表观遗传修饰（例如DNA甲基化）在血压相关基因，然而，这一领域仍然研究不足，在非洲裔美国人。我们使用了正在进行的代际血压研究的数据，（InterGEN），一项旨在调查非洲裔美国妇女（n=120）及其幼儿高血压风险因素的纵向研究，探讨压力负荷、问题解决应对、回避应对和社会支持应对与25个血压相关候选基因DNA甲基化的关系。结果：在位点水平分析中，压力负荷、问题解决应对、社会支持应对和回避应对分别与47、63、66和61个位点的甲基化水平相关，而压力负荷、问题解决应对、社会支持应对和回避应对分别与47、63、66和61个位点的甲基化水平相关。
BACKGROUND: Exposure to psychosocial stress and employment of high effort coping strategies have been identified as risk factors that may partially explain the high prevalence of hypertension among African Americans. One biological mechanism through which stress and coping may affect risk of hypertension is via epigenetic modifications (e.g. DNA methylation) in blood pressure-related genes, however this area remains understudied in African Americans.METHODS: We used data from the ongoing Intergenerational Blood Pressure Study (InterGEN), a longitudinal study designed to investigate factors that contribute to hypertension risk in African American women (n=120) and their young children, to investigate the association between stress overload, problem solving coping, avoidance coping, and social support coping with DNA methylation (DNAm) in 25 candidate genes related to blood pressure. Multivariable linear regression and multilevel modeling were used to conduct methylation site level and gene level analyses respectively.RESULTS: In site level analyses, stress overload, problem solving coping, social support coping, and avoidance coping were associated with 47, 63, 66, and 61 sites respectively at p