Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia
Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia
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DOI：
10.1016/j.leukres.2006.12.008
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发表时间：
2007-08-01
影响因子：
2.7
通讯作者：
Kojima, Seiji
中科院分区：
文献类型：
--
作者：
Hidaka, Hirokazu;Yagasaki, Hiroshi;Kojima, Seiji
中期因子（MK）是一种肝素结合生长因子，在许多实体癌中过表达。然而，在急性白血病中的表达尚未阐明。我们用实时荧光PCR检测了94例急性白血病患儿MK基因的表达。在41例B前体ALL患者中，30例MK基因表达高于正常BM。MK基因在半数以上的FAB M1、M2型AML患者中也有过表达。MK基因的实时定量PCR提供了一个特别的承诺，作为一个预后标志物和微小残留病的标志物在儿童与B-前体ALL。(c)2007爱思唯尔有限公司保留所有权利。
Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL. (c) 2007 Elsevier Ltd. All rights reserved.