Intrafamilial transmission of hepatitis C virus in Japan
Intrafamilial transmission of hepatitis C virus in Japan
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日本丙型肝炎病毒的家庭内传播
DOI：
10.1007/bf02781678
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Y. Ohta
中科院分区：
文献类型：
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作者：
K. Michitaka;M. Onji;N. Horiike;K. Kajino;I. Saito;T. Miyamura;Y. Ohta
为了研究丙型肝炎病毒（HCV）的家族内传播，采用酶联免疫吸附试验（ELISA）对16例慢性肝病患者的36名家庭成员进行了抗HCV（抗c100 -3）阳性筛查。16个家庭中有2个（12.5%）出现抗- hcv阳性个体聚集。35名无输血史的家庭成员中有4名（11.4%）抗- hcv阳性。抗- hcv阳性雌性17个子代中有2个（11.8%）为抗- hcv阳性，5个配偶中有1个（20.0%）为抗- hcv阳性。这些数据表明，家族内传播是HCV感染的可能途径之一。
SummaryTo study the intrafamilial transmission of hepatitis C virus (HCV), 36 family members of 16 patients with anti-HCV (anti-C100-3)-positive chronic liver disease were screened for anti-HCV by an enzymelinked immunosorbent assay (ELISA). Clusters of anti-HCV -positive individuals were observed in 2 of 16 families (12.5%). Four of 35 family members (11.4%) with no history of blood transfusion were positive for anti-HCV. Two of 17 offspring (11.8%) of anti-HCV-positive females were positive for anti-HCV, while 1 of 5 spouses (20.0%) was positive for anti-HCV. These data suggest that intrafamilial transmission is one of the possible routes of infection for HCV.