Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms
Multi-institutional dosimetric delivery assessment of intracranial stereotactic radiosurgery on different treatment platforms
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DOI：
10.1016/j.radonc.2020.05.024
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发表时间：
2020-06-01
影响因子：
5.7
通讯作者：
Clark, Catharine H.
中科院分区：
文献类型：
--
作者：
Dimitriadis, Alexis;Tsang, Yatman;Clark, Catharine H.
背景和目的：评估放射外科在不同的治疗platforms.Material和方法的剂量准确性：33个单馏分治疗计划进行了评估，在30个中心使用拟人头部模型与目标和脑干结构。目标是单个不规则形状的目标，类似于8 cc，距离脑干10 mm。体模被“固定”，扫描，计划和治疗后，当地的协议。EBT-XD电影和丙氨酸小球被用来测量绝对剂量，内的目标和脑干，并与TPS预测的剂量distributions.Results：PTV丙氨酸测量从龙门式直线加速器显示出的中位百分比差异的TPS为0.65%。与其他平台相比，射波刀（CK）的中位差异最高，为2.3%。伽玛刀（GK）显示最小中位数为0.3%。在OAR中观察到类似的趋势，丙氨酸测量结果显示，基于机架的直线加速器、CK和GK的中位百分比差异分别为1.1%、2.0%和0.4%。所有的平台表现出可比的伽马轴向和矢状面files.Conclusions之间的通过率：这种比较突出了测量和TPS计算的剂量为每个交付平台的剂量之间的变化。结果表明，所有治疗输送系统均可实现与预测剂量分布的临床可接受一致性。(c)2020 Elsevier B. V.保留所有权利。放射治疗与肿瘤学147（2020）153-161
Background and purpose: Assessment of dosimetric accuracy of radiosurgery on different treatment platforms.Material and methods: Thirty-three single fraction treatment plans were assessed at thirty centres using an anthropomorphic head phantom with target and brainstem structures. The target being a single irregular shaped target, similar to 8 cc, 10 mm from the brainstem. The phantom was "immobilised", scanned, planned and treated following the local protocols. EBT-XD films and alanine pellets were used to measure absolute dose, inside both the target and the brainstem, and compared with TPS predicted dose distributions.Results: PTV alanine measurements from gantry-based linacs showed a median percentage difference to the TPS of 0.65%. Cyberknife (CK) had the highest median difference of 2.3% in comparison to the other platforms. GammaKnife (GK) showed the smallest median of 0.3%. Similar trends were observed in the OAR with alanine measurements showing median percentage differences of1.1%, 2.0% and 0.4%, for gantry-based linacs, CK and GK respectively. All platforms showed comparable gamma passing rates between axial and sagittal films.Conclusions: This comparison has highlighted the dosimetric variation between measured and TPS calculated dose for each delivery platform. The results suggest that clinically acceptable agreement with the predicted dose distributions is achievable by all treatment delivery systems. (c) 2020 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 147 (2020) 153-161