Idiotype vaccination against murine B cell lymphoma. Inhibition of tumor immunity by free idiotype protein.
Idiotype vaccination against murine B cell lymphoma. Inhibition of tumor immunity by free idiotype protein.
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DOI：
10.4049/jimmunol.138.4.1289
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发表时间：
1987-02
影响因子：
4.4
通讯作者：
M. Kaminski;K. Kitamura;D. Maloney;R. Levy
中科院分区：
文献类型：
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作者：
M. Kaminski;K. Kitamura;D. Maloney;R. Levy
使用小鼠 B 细胞淋巴瘤 (38C13) 作为模型来研究独特型 (Id) 特异性肿瘤免疫的诱导。用源自肿瘤的Id蛋白对同基因小鼠进行免疫导致宿主产生抗Id抗体并诱导对肿瘤生长的抵抗状态。仅当 Id 蛋白与强免疫原性载体蛋白（例如匙孔血蓝蛋白或甲状腺球蛋白）缀合，并且在肿瘤攻击前至少 1 周施用缀合物时，才能建立肿瘤免疫。游离 Id 蛋白，例如存在于荷瘤动物中的游离 Id 蛋白，被发现以剂量依赖性方式抑制肿瘤免疫。虽然可以在预先存在血清Id蛋白的动物中诱导肿瘤免疫，但免疫状态的表达因可溶性蛋白的存在而受到抑制。
A murine B cell lymphoma (38C13) was used as a model to study the induction of idiotype (Id)-specific tumor immunity. Immunization of syngeneic mice with Id protein derived from the tumor resulted in the production of anti-Id antibodies by the host and in the induction of a state of resistance to tumor growth. Tumor immunity could be established only if the Id protein was conjugated to a strongly immunogenic carrier protein such as keyhole limpet hemocyanin or thyroglobulin, and if the conjugate was administered at least 1 week prior to tumor challenge. Free Id protein, such as that present in tumor bearing animals, was found to inhibit tumor immunity in a dose-dependent manner. Although tumor immunity could be induced in animals with pre-existent serum Id protein, the expression of the immune state was inhibited by the presence of the soluble protein.