Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
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DOI：
10.1186/1743-422x-5-33
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发表时间：
2008-02-27
期刊：
影响因子：
4.8
通讯作者：
Gould, Ernest A.
中科院分区：
文献类型：
--
作者：
de Lamballerie, Xavier;Leroy, Eric;Gould, Ernest A.
自2004年以来，非洲、印度洋、印度、亚洲和最近在欧洲发生了数百万例土著基孔肯雅病毒病病例。这种病毒通常由埃及伊蚊传播，现在已多次被认为与一种新的媒介Ae有关。白纹伊蚊。对全长病毒序列的分析揭示了病毒暴露于Ae的三个独立事件。白纹伊蚊，每一种之后都获得一个适应性突变，为这种蚊子的传播提供选择性优势。这一令人不安的、目前唯一的自然界“进化趋同”的例子说明了病原体对生态扰动的快速适应，这种适应是由人类活动直接驱动的。
Since 2004, several million indigenous cases of Chikungunya virus disease occurred in Africa, the Indian Ocean, India, Asia and, recently, Europe. The virus, usually transmitted by Aedes aegypti mosquitoes, has now repeatedly been associated with a new vector, Ae. Albopictus. Analysis of full-length viral sequences reveals three independent events of virus exposure to Ae. Albopictus, each followed by the acquisition of a single adaptive mutation providing selective advantage for transmission by this mosquito. This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities.