Atorvastatin Modulates Th1/Th2 Response in Patients With Chronic Heart Failure
Atorvastatin Modulates Th1/Th2 Response in Patients With Chronic Heart Failure
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阿托伐他汀调节慢性心力衰竭患者的 Th1/Th2 反应
DOI：
10.1016/j.cardfail.2008.10.001
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发表时间：
2009-03-01
影响因子：
6
通讯作者：
Liao, Yu-Hua
中科院分区：
文献类型：
--
作者：
Cheng, Xiang;Ding, Yingjun;Liao, Yu-Hua
背景：辅助性T细胞（Th）1/Th 2失衡与慢性心力衰竭（CHF）的发生有关。我们试图确定阿托伐他汀是否通过调节Th 1/Th2response.Methods和结果显示对CHF的任何影响：我们测定了白细胞介素（IL）-12，18，干扰素（IFN）-γ，IL-4的血清浓度。采用酶联免疫吸附法检测20例正常对照组和72例非缺血性CHF患者血清IL-10水平。为研究阿托伐他汀在体内的作用，将CHF患者分为常规治疗组（n = 35）和常规治疗加阿托伐他汀（10 mg/d）组（n = 37）。在入院时和治疗后2周测量患者血清IFN-γ和IL-4水平。分别在阿托伐他汀（0、0.4、1和4 μ mol/L）存在或不存在的情况下体外培养CHF组患者外周血单个核细胞，检测IFN-γ和IL-4水平。CHF组血清IL-12、IL-18和IFN-γ水平显著高于对照组。IFN-γ水平和IFN-γ：IL-4的比例与阿托伐他汀治疗在体内和体外显着降低，而IL-4的水平没有显着差异。结论：CHF患者存在Th 1极化。阿托伐他汀可通过抑制Th 1细胞因子的产生来调节Th 1/Th 2反应。（J Cardiac Fail 2009;15：158-162）
dBackground: The T-helper (Th)1/Th2 imbalance has been demonstrated to be involved in chronic heart failure (CHF). We sought to determine whether atorvastatin exhibited any effect on CHF through modulating the Th1/Th2 response.Methods and Results: We measured serum concentrations of interleukin(IL)-12, -18, interferon(IFN)-gamma, IL-4. and IL-10 from 20 controls and 72 patients with nonischemic CHF by enzyme-linked immunosorbent assay. To investigate the effect of atorvastatin in vivo, CHF patients were either classified into a Usual therapy group (n = 35) or usual therapy Plus atorvastatin ( 10 mg/day) group (it = 37). Patient serum levels of IFN-gamma and IL-4 were measured at time of admission and 2 weeks after treatment. Peripheral blood mononuclear cells from patients of CHF g-roup were Cultured in the presence or absence of atorvastatin (0, 0.4, 1, and 4 mu mol/L) in vitro, and IFN-gamma and IL-4 levels were detected. Serum levels of IL-12, IL-18, and IFN-gamma were significantly higher in the CHF group than in the control group. The levels of IFN-gamma and the ratios of IFN-gamma:IL-4 were significantly decreased with atorvastatin treatment both in vivo and in vitro, whereas levels of IL-4 did not differ significantly.Conclusions: Th1 polarization exists in patients with CHF. and atorvastatin can modulate the Th1/Th2 response through inhibiting Th I cytokine production. (J Cardiac Fail 2009;15:158-162)