Socio-Economic Status and Health: Evaluation of Human Biomonitored Chemical Exposure to Per- and Polyfluorinated Substances across Status
Socio-Economic Status and Health: Evaluation of Human Biomonitored Chemical Exposure to Per- and Polyfluorinated Substances across Status
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DOI：
10.3390/ijerph15122818
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发表时间：
2018-12-01
影响因子：
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通讯作者：
Schoeters, Greet
中科院分区：
文献类型：
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作者：
Buekers, Jurgen;Colles, Ann;Schoeters, Greet
关于环境、健康和福祉关系（EHWB）的研究正在从孤立的方法转向包括社会经济背景的系统方法。为了进一步解开社会暴露和内部化学暴露之间复杂的相互作用，我们对人类生物监测（HBM）研究进行了荟萃分析，其中包括全氟烷基物质和多氟烷基物质（PFASs）的内部暴露数据以及风险因素的详细信息，包括研究人群的社会经济地位描述符（SES）。全氟辛烷磺酸在自然界中是持久性的，其中一些具有干扰内分泌的特性。个别研究表明，PFASs的HBM生物标志物浓度通常随着SES指标（例如收入指标）的增加而增加。基于对PFASs和SES指标之间关联的荟萃分析（五项研究），可以估计其关联程度。对于SES指标收入，收入的变化用一个因子变化来表示，这个因子变化通过基尼系数来修正，以考虑到研究之间收入类别的差异，以及国家之间的收入范围。就社会经济地位指标教育而言，我们必须得出结论：描述符(
Research on the environment, health, and well-being nexus (EHWB) is shifting from a silo toward a systemic approach that includes the socio-economic context. To disentangle further the complex interplay between the socio-exposome and internal chemical exposure, we performed a meta-analysis of human biomonitoring (HBM) studies with internal exposure data on per-and polyfluoroalkyl substances (PFASs) and detailed information on risk factors, including descriptors of socio-economic status (SES) of the study population. PFASs are persistent in nature, and some have endocrine-disrupting properties. Individual studies have shown that HBM biomarker concentrations of PFASs generally increase with SES indicators, e.g., for income. Based on a meta-analysis (five studies) of the associations between PFASs and SES indicators, the magnitude of the association could be estimated. For the SES indicator income, changes in income were expressed by a factor change, which was corrected by the Gini coefficient to take into account the differences in income categories between studies, and the income range between countries. For the SES indicator education, we had to conclude that descriptors (