Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study
Efficacy of cryotherapy associated with laser therapy for decreasing severity of melphalan-induced oral mucositis during hematological stem-cell transplantation: a prospective clinical study
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DOI：
10.1002/hon.2133
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发表时间：
2015-09-01
影响因子：
3.3
通讯作者：
Correa, Luciana
中科院分区：
文献类型：
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作者：
Eduardo, Fernanda de Paula;Bezinelli, Leticia Mello;Correa, Luciana
美法仑后造血干细胞移植（HSCT）是多发性骨髓瘤和其他造血系统肿瘤的标准治疗。然而，高剂量的美法仑会引起严重的口腔粘膜炎（OM）。目的是验证冷冻联合激光治疗对降低OM严重程度的有效性。接受马法兰化疗的HSCT患者（n = 71）根据OM治疗随机分为两组：用冰刀进行口腔冷冻治疗1 h 35 min，然后进行低强度激光治疗（InGaAIP，660 nm，40 mW，6 J/cm（2））（n = 54）和单独激光治疗（n = 17）。对照组（它= 33）由接受美法仑治疗的HSCT患者组成，这些患者未接受针对OM的特异性治疗。从DO至D +11收集OM评分和临床信息。与其他组相比，冷冻治疗/激光治疗组显示出最低的OM评分（最高I级）和最低的OM平均天数（8天）（p
Melphalan followed by hematopoietic stem-cell transplantation (HSCT) is the standard treatment for multiple myeloma and other hematopoietic neoplasms. However, high doses of melphalan cause severe oral mucositis (OM). The objective was to verify the efficacy of cryotherapy plus laser therapy on reduction of OM severity. HSCT patients undergoing melphalan chemotherapy (n = 71) were randomly divided into two groups according to OM treatment: oral cryotherapy performed with ice chips for 1 h 35 min followed by low-level laser therapy (InGaAIP, 660 nm, 40 mW, 6 J/cm(2)) (n = 54) and laser therapy alone with the same protocol (n = 17). A control group (it = 33) was composed of HSCT patients treated with melphalan who received no specific treatment for OM. OM scores and clinical information were collected from DO to D +11. The cryotherapy/laser therapy group showed the lowest OM scores (maximum Grade I) and the lowest mean number of days (8 days) with OM in comparison with the other groups (p