Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting.
Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting.
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DOI：
10.3233/blc-150037
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发表时间：
2016-01-07
期刊：
影响因子：
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通讯作者：
Real FX
中科院分区：
文献类型：
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作者：
Lerner SP;McConkey DJ;Hoadley KA;Chan KS;Kim WY;Radvanyi F;Höglund M;Real FX
组学技术的出现是膀胱癌分子亚分类的关键。几个小组为此目的采用了不同的战略，其结果部分重叠。在西班牙国家癌症研究中心（CNIO）举行的会议讨论了这些分类，并在适当的情况下达成共识。在对参加会议的团队所做的工作进行更新介绍后，就存在一组基底鳞状细胞样肿瘤（称为BASQ）达成了共识，其特征是KRT 5/6和KRT 14的高表达以及FOXA 1和GATA 3的低/不可检测的表达。另外一个具有尿路上皮分化特征的肿瘤亚组被确认，需要其最佳分子定义。对于描述的其他亚型，需要更多的工作来确定它们的稳健性以及如何在分子水平上最好地定义它们。
The advent of Omics technologies has been key to the molecular subclassification of urothelial bladder cancer. Several groups have used different strategies to this aim, with partially overlapping findings. The meeting at the Spanish National Cancer Research Center-CNIO was held to discuss such classifications and reach consensus where appropriate. After updated presentations on the work performed by the teams attending the meeting, a consensus was reached regarding the existence of a group of Basal-Squamous-like tumors – designated BASQ – charaterized the high expression of KRT5/6 and KRT14 and low/undetectable expression of FOXA1 and GATA3. An additional tumor subgroup with urothelial differentiation features was recognized whose optimal molecular definition is required. For other subtypes described, more work is needed to determine how robust they are and how to best define them at the molecular level.