Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.
Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.
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DOI：
10.1002/cne.23617
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发表时间：
2014-08-15
影响因子：
2.5
通讯作者：
Lipton, Stuart A.
中科院分区：
文献类型：
--
作者：
Ambasudhan, Rajesh;Dolatabadi, Nima;Nutter, Anthony;Masliah, Eliezer;McKercher, Scott R.;Lipton, Stuart A.
关键词：
神经移植是一种很有前途的策略，用于恢复多巴胺能功能障碍和改善帕金森病（PD）的疾病进展。人胚胎干细胞（hESC）是这方面的潜在资源，因为它们能够提供几乎无限的同质多巴胺能祖细胞和适当谱系的神经元的供应。最近的进展，在发展强大的细胞培养方案的hESC定向分化为近纯群体的腹侧中脑（A9型）多巴胺能神经元提高了PD细胞治疗的前景。在这里，我们集中我们的审查，目前国家的最先进的技术，利用hESC为基础的战略发展的干细胞治疗PD。重要的是，我们还简要描述了一种新的遗传编程方法，可以解决该领域仍然存在的许多关键挑战，并可能加速临床翻译。
Neural transplantation is a promising strategy for restoring dopaminergic dysfunction and modifying disease progression in Parkinson's disease (PD). Human embryonic stem cells (hESCs) are a potential resource in this regard because of their ability to provide a virtually limitless supply of homogenous dopaminergic progenitors and neurons of appropriate lineage. The recent advances in developing robust cell culture protocols for directed differentiation of hESCs to near pure populations of ventral mesencephalic (A9-type) dopaminergic neurons has heightened the prospects for PD cell therapy. Here, we focus our review on current state-of-the-art techniques for harnessing hESC-based strategies toward development of a stem cell therapeutic for PD. Importantly, we also briefly describe a novel genetic-programming approach that may address many of the key challenges that remain in the field and that may hasten clinical translation.
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DOI：
10.1523/jneurosci.0534-12.2012
发表时间：
2012-09-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lyons MR;Schwarz CM;West AE
通讯作者：
West AE
影响因子：
64.8
作者：
Kriks, Sonja;Shim, Jae-Won;Piao, Jinghua;Ganat, Yosif M.;Wakeman, Dustin R.;Xie, Zhong;Carrillo-Reid, Luis;Auyeung, Gordon;Antonacci, Chris;Buch, Amanda;Yang, Lichuan;Beal, M. Flint;Surmeier, D. James;Kordower, Jeffrey H.;Tabar, Viviane;Studer, Lorenz
通讯作者：
Studer, Lorenz
影响因子：
3.5
作者：
Chung, S;Hedlund, E;Kim, KS
通讯作者：
Kim, KS
影响因子：
5.2
作者：
Brederlau, Anke;Correia, Ana Sofia;Li, Jia-Yi
通讯作者：
Li, Jia-Yi
影响因子：
23.9
作者：
Ambasudhan R;Talantova M;Coleman R;Yuan X;Zhu S;Lipton SA;Ding S
通讯作者：
Ding S