The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis
The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis
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DOI：
10.2741/2700
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Hume, David A.
中科院分区：
文献类型：
--
作者：
Bonifer, Constanze;Hume, David A.
集落刺激因子1受体(CSF-1R)是巨噬细胞分化所必需的酪氨酸激酶受体，在造血过程中起着重要作用。CSF1R基因缺陷的小鼠在巨噬细胞的发育、繁殖和组织重塑方面表现出多种缺陷。此外，该基因的解除管制是许多肿瘤的一个标志。这包括抑制急性髓系白血病的表达和某些实体肿瘤的异常激活，如乳腺癌。因此，这个基因的表达需要严格控制。该综述总结了实验，为CSF1R基因表达的转录调控提供了详细的图片。除了与造血直接相关外，对CSF1R转录调控的研究为理解控制哺乳动物细胞命运的分子机制提供了一个模型。
The colony-stimulating-factor 1 receptor (CSF-1 R) is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. Mice deficient for the csf1r gene show multiple defects in macrophage development, reproduction and tissue remodeling. Moreover, deregulation of this gene is a hallmark of many tumors. This includes repression of expression in acute myeloid leukemia and aberrant activation in certain solid tumors, such as breast cancer. Expression of this gene therefore needs to be tightly controlled. This review summarizes experiments providing a detailed picture of how transcription of csf1r gene expression is regulated. Aside from the direct relevance to hematopoiesis, studies of csf1r transcriptional regulation provide a model for understanding the molecular mechanisms that control mammalian cell fate.