Comparative lesion sequencing provides insights into tumor evolution
Comparative lesion sequencing provides insights into tumor evolution
复制标题
DOI：
10.1073/pnas.0712345105
复制
发表时间：
2008-03-18
影响因子：
11.1
通讯作者：
Markowitz, Sanford D.
中科院分区：
文献类型：
--
作者：
Jones, Sian;Chen, Wei-dong;Markowitz, Sanford D.
我们表明，可以通过分析其共同的突变来确定良性，侵入性和转移性肿瘤细胞的诞生的时间。当与先前的临床观察结合结合时，这些分析表明，关于结直肠肿瘤发生的一般结论：（i）大良性肿瘤发展为晚期癌症，但大约需要17年
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes approximate to 17 years for a large benign tumor to evolve into an advanced cancer but