Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [O-15]H2O PET study during single-trial Stroop task performance
Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [O-15]H2O PET study during single-trial Stroop task performance
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DOI：
10.1176/ajp.154.12.1670
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发表时间：
1997-12-01
影响因子：
17.7
通讯作者：
Cohen, JD
中科院分区：
文献类型：
--
作者：
Carter, CS;Mintun, M;Cohen, JD
目的：注意缺陷是精神分裂症患者认知功能障碍的一个突出方面。前扣带回被认为是额叶注意控制系统的重要组成部分。在精神分裂症中，这一区域的结构和功能异常已被报道，但它们与注意力缺陷的关系尚不清楚。作者研究了与精神分裂症患者选择性注意相关的前扣带回和相关神经系统的功能。方法：当受试者执行单次Stroop任务的多个块时，获得[O-15]H2O正电子发射断层扫描。14名精神分裂症患者与15名年龄、性别和父母教育程度相匹配的正常受试者进行比较。结果：精神分裂症患者在颜色不一致条件下的反应率相同，但在颜色命名上的错误更多。与作者的假设一致，精神分裂症患者在说出颜色不一致刺激的颜色时，前扣带回的激活明显减少。结论：精神分裂症患者在选择性注意表现时，前扣带回未被激活。这一发现增加了对精神分裂症中结构和代谢异常的功能意义的理解，这些异常之前在大脑的这一区域被报道过。
Objective: Attentional deficits are a prominent aspect of cognitive dysfunction in schizophrenia. The anterior cingulate gyrus is proposed to be an important component of frontal attentional control systems. Structural and functional abnormalities have been reported in this region in schizophrenia, but their relationship to attentional deficits is unknown. The authors investigated the function of the anterior cingulate gyrus and the related neural systems that are associated with selective attention in patients with schizophrenia. Method: While subjects performed multiple blocks of a single-trial Stroop task, [O-15]H2O positron emission tomography scans were obtained. Fourteen patients with schizophrenia were compared with 15 normal subjects matched for age, gender, and parental education. Results: The patients with schizophrenia responded at the same rate but made more errors in color naming during the color-incongruent condition. Consistent with the authors' hypothesis, patients with schizoephrenia showed significantly less anterior cingulate gyrus activation while naming the color of color-incongruent stimuli. Conclusions: Patients with schizophrenia fail to activate the anterior cingulate gyrus during selective attention performance. This finding adds to the understanding of the functional significance of the structural and metabolic abnormalities in schizophrenia that have been previously reported in this region of the brain.