The Th17/Treg imbalance in patients with acute coronary syndrome
The Th17/Treg imbalance in patients with acute coronary syndrome
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急性冠脉综合征患者Th17/Treg失衡
DOI：
10.1016/j.clim.2008.01.009
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发表时间：
2008-04-01
影响因子：
8.6
通讯作者：
Liao, Yu-hua
中科院分区：
文献类型：
--
作者：
Cheng, Xiang;Yu, Xian;Liao, Yu-hua
动脉粥样硬化是一种由T淋巴细胞亚群调控的慢性炎症性疾病。近期，CD4 + CD25 + Foxp3 +调节性T细胞（Treg）和Th17细胞被描述为不同于Th1和Th2细胞的两个独特亚群，并且在自身免疫方面具有相反的作用。Th17/Treg平衡控制炎症，并且可能在斑块不稳定的发病机制以及急性冠状动脉综合征[ACS，包括不稳定型心绞痛（UA）和急性心肌梗死（AMI）]的发作中起重要作用。为了评估这种平衡在冠心病患者中是否被打破，我们在不同层面检测了Th17/Treg的功能，包括急性心肌梗死、不稳定型心绞痛、稳定型心绞痛（SA）患者以及对照组的细胞频率、相关细胞因子分泌以及关键转录因子。结果表明，与稳定型心绞痛患者和对照组相比，急性冠状动脉综合征患者外周血Th17数量、Th17相关细胞因子（白细胞介素 - 17、白细胞介素 - 6和白细胞介素 - 23）以及转录因子（RORγt）水平显著升高，而Treg数量、Treg相关细胞因子（白细胞介素 - 10和转化生长因子 - β1）以及转录因子（Foxp3）水平明显降低。结果表明急性冠状动脉综合征患者存在Th17/Treg功能失衡，提示Th17/Treg失衡在斑块不稳定和急性冠状动脉综合征发作中具有潜在作用。（C）2008爱思唯尔公司。保留所有权利。
Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4+CD25+Foxp3+ regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets from Th1 and Th2 cells and have the opposite effects on autoimmunity. Th17/Treg balance controls inflammation and may be important in the pathogenesis of plaque destabilization and the onset of acute coronary syndrome [ACS, including unstable angina (UA) and acute myocardial infarction (AMI)]. To assess whether this balance was broken in patients with coronary heart disease, we detected Th17/Treg functions on different levels including cell frequencies, related cytokine secretion and key transcription factors in patients with AMl, UA, stable angina (SA) and controls. The results demonstrated that patients with ACS revealed significant increase in peripheral Th17 number, Th17 related cytokines (IL-17, IL-6 and IL-23) and transcription factor (ROR gamma t) levels and obvious decrease in Treg number, Treg related cytokines (IL-10 and TGF-beta 1) and transcription factor (Foxp3) levels as compared with patients with SA and controls. Results indicate that Th17/Treg functional imbalance exists in patients with ACS, suggesting a potential role for Th17/Treg imbalance in plaque destabilization and the onset of ACS. (C) 2008 Elsevier Inc. All rights reserved.