Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy
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DOI：
10.1093/brain/awq070
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发表时间：
2010-05-01
期刊：
影响因子：
14.5
通讯作者：
Jefferys, John G. R.
中科院分区：
文献类型：
--
作者：
Jiruska, Premysl;Finnerty, Gerald T.;Jefferys, John G. R.
高频皮层活动，特别是在250-600 Hz（快速涟漪）带，已被牵连在癫痫发生和癫痫发作的产生中发挥至关重要的作用。快速波动对癫痫发作起始区具有高度特异性。然而，快纹波与癫痫灶相关的证据取决于动物模型和海马硬化形式的实质性病变的人类病例，这表明快纹波可能需要神经元丢失。在目前的工作中，我们测试是否细胞损失是一个必要的先决条件，快速纹波的产生，使用颞叶癫痫，没有海马硬化的非病变模型。模型采用单侧海马内注射破伤风毒素的方法。自由移动的癫痫大鼠的大脑半球记录显示了高频活动（> 100 Hz），包括快速波动。发作间期放电和癫痫发作期间都存在高频活动。发作间期快速波动被证明是一个显着更可靠的标志物的主要致痫区比发作间期放电或波纹（100-250赫兹）的存在。这些结果表明，快速涟漪活动应考虑其潜在价值的术前检查的非病灶性颞叶癫痫。
High-frequency cortical activity, particularly in the 250-600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone. However, evidence for the association of fast ripples with epileptic foci depends on animal models and human cases with substantial lesions in the form of hippocampal sclerosis, which suggests that neuronal loss may be required for fast ripples. In the present work, we tested whether cell loss is a necessary prerequisite for the generation of fast ripples, using a non-lesional model of temporal lobe epilepsy that lacks hippocampal sclerosis. The model is induced by unilateral intrahippocampal injection of tetanus toxin. Recordings from the hippocampi of freely-moving epileptic rats revealed high-frequency activity (> 100 Hz), including fast ripples. High-frequency activity was present both during interictal discharges and seizure onset. Interictal fast ripples proved a significantly more reliable marker of the primary epileptogenic zone than the presence of either interictal discharges or ripples (100-250 Hz). These results suggest that fast ripple activity should be considered for its potential value in the pre-surgical workup of non-lesional temporal lobe epilepsy.