Role of curcumin in the treatment of acute kidney injury: research challenges and opportunities
Role of curcumin in the treatment of acute kidney injury: research challenges and opportunities
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DOI：
10.1016/j.phymed.2022.154306
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发表时间：
2022-09-01
期刊：
影响因子：
7.9
通讯作者：
Wan, Chunpeng Craig
中科院分区：
文献类型：
--
作者：
Cai, Yi;Huang, Chaoming;Wan, Chunpeng Craig
背景资料：急性肾损伤（acute kidney injury，阿基）是临床住院患者常见的并发症，尽管临床采取了多种治疗措施，但其发病率和死亡率仍居高不下。阿基是由感染、手术、重金属暴露和药物副作用引发的，但目前的化学药物往往达不到阿基治疗的预期，而且有毒副作用。因此，寻找新的干预和治疗方法，特别是天然来源的干预和治疗方法，具有显著的临床意义和应用价值。草药单体姜黄素是从植物姜黄中提取的天然酚类化合物，具有多种生物活性，包括阿基。此外，最近的研究表明，姜黄素通过调节免疫系统和炎症介质的释放，清除氧自由基，减少细胞凋亡和改善线粒体动力学来恢复肾功能。然而，姜黄素的生物利用度低，限制了其临床应用。因此，研究姜黄素对急性肾损伤的治疗作用及其分子机制，提高姜黄素的生物利用度，对于姜黄素制剂的开发和临床应用具有重要意义。目的：本文综述了姜黄素的来源、药代动力学和临床应用的局限性，并探讨了利用纳米技术优化其生物利用度的方法。重点阐述姜黄素对阿基的治疗作用及其分子机制，为临床治疗阿基提供理论依据。研究方法：本综述通过检索3个数据库（Web of Science、PubMed和Science Direct）进行了专门检索，截止日期为2021年12月。检索词为“姜黄素”、“急性肾损伤”、“阿基”、“
Background: Acute kidney injury (AKI) is a common complication in clinical inpatients, and it continues a high morbidity and mortality rate despite many clinical treatment measures. AKI is triggered by infections, surgery, heavy metal exposure and drug side effects, but current chemical drugs often fall short of expectations for AKI treatment and have toxic side effects. Therefore, finding new interventions and treatments, especially of natural origin, is of remarkable clinical significance and application. The herbal monomer curcumin is a natural phenolic compound extracted from the plant Curcuma longa and showed various biological activities, including AKI. Furthermore, recent studies have shown that curcumin restores renal function by modulating the immune system and the release of inflammatory mediators, scavenging oxygen free radicals, reducing apoptosis and improving mitochondrial dynamics. However, curcumin has a low bioavailability, which limits its clinical application. For this reason, it is essential to investigate the therapeutic effects and molecular mechanisms of curcumin in AKI, as well as to improve its bioavailability for curcumin formulation development and clinical application. Purpose: This review summarizes the sources, pharmacokinetics, and limitations in the clinical application of curcumin and explores methods to optimize its bioavailability using nanotechnology. In particular, the therapeutic effects and molecular mechanisms of curcumin on AKI are highlighted to provide a theoretical basis for AKI treatment in clinical practices. Methods: This review was specifically searched by means of a search of three databases (Web of Science, PubMed and Science Direct), till December 2021. Search terms were "Curcumin", "Acute kidney injury", "AKI", "