mRNA surveillance: the perfect persist.
mRNA surveillance: the perfect persist.
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发表时间：
2002-08
影响因子：
4
通讯作者：
E. Wagner;J. Lykke-Andersen
中科院分区：
文献类型：
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作者：
E. Wagner;J. Lykke-Andersen
在真核生物中，已经进化出一套复杂的机制，以确保基因表达的多步骤过程得到准确执行并适应细胞需求。在这种情况下，信使核糖核酸监测途径通过评估信使核糖核酸的质量来确保它们适合翻译。信使核糖核酸监测促进了含有提前终止密码子的信使核糖核酸的检测和破坏，这一过程被称为无义介导的衰变。此外，最近的研究表明，一种不同的mRNA监控过程，称为不间断衰变，负责耗尽缺乏框架内终止密码子的mRNA。因此，对信使核糖核酸的监测可以阻止截短或异常蛋白质的合成，这些蛋白质可能具有显性负效应和其他有害影响。
In eukaryotes, an elaborate set of mechanisms has evolved to ensure that the multistep process of gene expression is accurately executed and adapted to cellular needs. The mRNA surveillance pathway works in this context by assessing the quality of mRNAs to ensure that they are suitable for translation. mRNA surveillance facilitates the detection and destruction of mRNAs that contain premature termination codons by a process called nonsense-mediated decay. Moreover, recent studies have shown that a distinct mRNA surveillance process, called nonstop decay, is responsible for depleting mRNAs that lack in-frame termination codons. mRNA surveillance thereby prevents the synthesis of truncated and otherwise aberrant proteins, which can have dominant-negative and other deleterious effects.