A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics.
A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics.
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DOI：
10.1080/10255842.2015.1052417
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发表时间：
2016
影响因子：
1.6
通讯作者：
Vande Geest JP
中科院分区：
文献类型：
--
作者：
Ayyalasomayajula A;Park RI;Simon BR;Vande Geest JP
进行性视野恶化是原发性开角型青光眼（POAG）的特征性表现，视神经乳头（ONH）的生物力学被认为在其发病过程中起重要作用。我们使用多孔超弹性来模拟眼组织的复杂多孔行为，以更好地理解眼材料性质的变化对ONH生物力学的影响。构建人眼的轴对称模型，以参数化地研究视网膜-布鲁赫脉络膜复合体（kRBC）、巩膜（ksclera）、葡萄膜巩膜通路（kUVSC）和小梁网（kTM）的渗透性的变化以及筛板（LC）和巩膜的刚度的变化如何影响IOP、LC应变和跨层间质压梯度（TLIPG）。将kRBC从5×10− 12 m/s降低到5×10− 13 m/s，IOP和LC应变增加17%，TLIPG增加21%。当巩膜和LC模量分别降低48%和50%时，LC应变分别增加13%和9%。除了小梁网和葡萄膜巩膜通路外，视网膜-布鲁赫-脉络膜复合体对IOP、LC应变和TLIPG具有重要影响。kRBC和巩膜模量的变化导致IOP和LC应变的非线性变化，特别是在最低的kTM和kUVSC下。这项研究表明，多孔超弹性建模提供了一种新的方法，计算研究的生物力学环境的ONH。眼组织的多孔超弹性模拟可能有助于进一步了解POAG后眼组织的复杂生物力学环境。
Progressively deteriorating visual field is a characteristic feature of primary open-angle glaucoma (POAG), and the biomechanics of optic nerve head (ONH) is believed to be important in its onset. We used porohyperelasticity to model the complex porous behavior of ocular tissues to better understand the effect variations in ocular material properties can have on ONH biomechanics. An axisymmetric model of the human eye was constructed to parametrically study how changes in the permeabilities of retina-Bruch's-choroid complex (kRBC), sclera (ksclera), uveoscleral pathway (kUVSC), and trabecular meshwork (kTM) as well as how changes in the stiffness of the lamina cribrosa (LC) and sclera affect IOP, LC strains, and translaminar interstitial pressure gradients (TLIPG). Decreasing kRBC from 5×10−12m/s to 5×10−13m/s increased IOP and LC strains by 17%, and TLIPG by 21%. LC strains increased by 13% and 9% when the scleral and LC moduli were decreased by 48% and 50%, respectively. In addition to the trabecular meshwork and uveoscleral pathway, the retina-Bruch's-choroid complex had an important effect on IOP, LC strains, and TLIPG. Changes in kRBC and scleral modulus resulted in nonlinear changes in the IOP, and LC strains especially at the lowest kTM and kUVSC. This study demonstrates that porohyperelastic modeling provides a novel method for computationally studying the biomechanical environment of the ONH. Porohyperelastic simulations of ocular tissues may help provide further insight into the complex biomechanical environment of posterior ocular tissues in POAG.