Isopimarane Diterpenoids from the Rhizomes of Kaempferia marginata and Their Potential Anti-inflammatory Activities
Isopimarane Diterpenoids from the Rhizomes of Kaempferia marginata and Their Potential Anti-inflammatory Activities
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DOI：
10.1021/acs.jnatprod.9b00307
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发表时间：
2020-01-01
影响因子：
5.1
通讯作者：
Suksamrarn, Apichart
中科院分区：
文献类型：
--
作者：
Chokchaisiri, Ratchanaporn;Chaichompoo, Waraluck;Suksamrarn, Apichart
从山茶根状茎中分离得到6个新的异海松烷二萜类化合物：边醇A-F(1-6)和8个已知化合物(7-14)。根据光谱方法，结合ECD实验和计算数据，并与文献值进行比较，确定了1-6的结构和绝对构型。在脂多糖激活的RAW264.7细胞中测试了大部分分离的化合物对一氧化氮(NO)的抑制作用。其中，甘露醇B(2)能降低小鼠巨噬细胞的NO水平，其IC50值为28.1+/-1.7mU/M。
Six new isopimarane diterpenes, marginaols A-F (1-6), along with eight known compounds (7-14), were isolated from the rhizomes of Kaempferia marginata. The structures and absolute configurations of 1-6 were established on the basis of spectroscopic methods and the experimental and calculated ECD data as well as comparison with the literature values. Most of the isolated compounds were tested for their nitric oxide (NO) inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, marginaol B (2) was found to reduce NO levels in murine macrophage cells with an IC50 value of 28.1 +/- 1.7 mu M.