Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig
Expression of p-glycoprotein is associated with that of multidrug resistance protein 1 (MRP1) in the vestibular labyrinth and endolymphatic sac of the guinea pig
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DOI：
10.1016/s0304-3940(01)01738-4
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发表时间：
2001-05-11
影响因子：
2.5
通讯作者：
Saito, H
中科院分区：
文献类型：
--
作者：
Saito, T;Zhang, ZJ;Saito, H
采用抗p-糖蛋白单克隆抗体（mAb） C219和抗mrp单抗MRPr1免疫组化染色，检测豚鼠前庭迷路和内淋巴囊中p-糖蛋白（p-gp）和多药耐药蛋白1 （MRP1）的表达。壶腹嵴、室、囊和ES毛细血管内皮细胞均检测到P-gp。MRP1在壶腹嵴上皮、胞室、囊泡和ES上皮细胞中检测到。由于p-gp和MRP1作为挤压泵，它们可能在前庭器官和ES中相互协调，在血迷宫屏障中发挥重要作用。(C) 2001年由爱思唯尔科学爱尔兰有限公司出版。
Expression of p-glycoprotein (p-gp) and multidrug resistance protein 1 (MRP1) was detected in the vestibular labyrinth and endolymphatic sac (ES) of the guinea pig by immunohistochemical staining using anti-p-gp monoclonal antibody (mAb) C219 and anti-MRP mAb MRPr1. P-gp was detected in capillary endothelial cells of the crista ampullaris, utricle, saccule and ES. MRP1 was detected in the epithelial lining of the crista ampullaris, utricle, saccule, and epithelial cells of the ES. Since p-gp and MRP1 act as extrusion pumps, they may coordinate with each other in vestibular organs and ES and play an important role in the blood-labyrinth barrier. (C) 2001 Published by Elsevier Science ireland Ltd.