A variety of glial pathological structures by the modified Gallyas-Braak method
A variety of glial pathological structures by the modified Gallyas-Braak method
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DOI：
10.1111/j.1440-1789.1996.tb00168.x
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发表时间：
1996-06-01
期刊：
影响因子：
2.3
通讯作者：
Oda, M
中科院分区：
文献类型：
--
作者：
Arai, N;Oda, M
本文介绍了近年来对tau蛋白阳性胶质细胞异常结构及其临床病理意义的认识。本文所概述的具有tau蛋白抗原表位的神经胶质细胞异常结构包括（i）簇状星形胶质细胞，（ii）棘状星形胶质细胞，（iii）胶质卷曲体，（iv）嗜银丝，（v）烟花样结构和（vi）嗜银血管周围星形胶质细胞足。这项研究的结论是，簇状星形胶质细胞在进行性核上性麻痹（PSP）的情况下是有利的，并且在皮质基底节变性（CBD）的原型中存在大量嗜银线和烟花样结构的特征，与这些结构不同，在更广泛的神经系统疾病如PSP中观察到胶质卷曲体，CBD和其他一些病例的神经纤维缠结的过早出现，虽然胶质卷曲体在常规实验室检查中是罕见的，并且它们的构型并不总是均匀的，因此，改良的Gallyas-Braak方法对于诊断一些伴有tau异常的神经退行性疾病是有用的，然而，必须指出的是，该方法也可以在多种条件下，特别是在PSP和CBD中，在多系统萎缩或grumose或泡沫球体中，对tau阴性结构如胶质细胞胞质内含物（少突胶质细胞微管缠结）进行检测。
Recent knowledge on tau-positive glial abnormal structures and their clinico-pathological significance were introduced, The structures outlined here, which are strikingly visualized by the modified Gallyas-Braak method and have tau-epitopes, included (i) tuft-shaped astrocytes, (ii) thorn-shaped astrocytes, (iii) glial coiled bodies, (iv) argyrophilic threads, (v) firework-like structures and (vi) argyrophilic perivascular astrocytic feet, This study concludes that the tuft-shaped astrocytes are favored in cases of progressive supranuclear palsy (PSP), and that there is a massive appearance of both the argyrophilic threads and the firework-like structures characteristic in prototype of corticobasal degeneration (CBD), Unlike these structures, glial coiled bodies were observed in a wider range of neurological diseases such as PSP, CBD and some other cases with precocious appearance of the neurofibrillary tangles, although the glial coiled bodies were rare in routine laboratory examination and were not always uniform in their configuration, Thus, the modified Gallyas-Braak method is useful for the diagnosing of some neurodegenerative diseases with tau abnormalities, especially of PSP and CBD, It must be noted, however, that this method could also impregnate tau-negative structures such as glial cytoplasmic inclusions (oligodendroglial microtubular tangles) in multiple system atrophy or grumose or foamy spheroid body in various conditions, especially in PSP and CBD.