Smart Flexible Electronics-Integrated Wound Dressing for Real-Time Monitoring and On-Demand Treatment of Infected Wounds
Smart Flexible Electronics-Integrated Wound Dressing for Real-Time Monitoring and On-Demand Treatment of Infected Wounds
复制标题
智能柔性电子集成伤口敷料，用于实时监测和按需治疗感染伤口
DOI：
10.1002/advs.201902673
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发表时间：
2020-01-10
期刊：
影响因子：
15.1
通讯作者：
Wu, Zhaohui
中科院分区：
文献类型：
--
作者：
Pang, Qian;Lou, Dong;Wu, Zhaohui
感染作为最常见的创面并发症，已成为创面管理的主要临床挑战。为了克服伤口愈合过程中的“黑匣子”状态，具有实时监测、早期诊断和按需治疗能力的下一代伤口敷料备受关注。本文结合生物电子学的新兴发展，设计了一种双层结构的柔性电子集成智能伤口敷料，其上层是聚二甲基硅氧烷封装的柔性电子集成温度传感器和紫外线发光二极管，下层是紫外线响应抗菌水凝胶。这种敷料有望通过集成传感器实时监测伤口温度来提供早期感染诊断，并通过原位紫外线照射从水凝胶中释放抗生素来按需治疗感染。该集成系统具有良好的灵活性、良好的兼容性、较高的监测灵敏度和耐久性。动物实验结果表明，该集成系统能够实时监测伤口状态，检测细菌感染，并根据需要提供有效的治疗。这项概念验证研究在开发新策略以显著改善伤口管理和其他病理诊断和治疗方面具有很大的前景。
As the most frequent wound complication, infection has become a major clinical challenge in wound management. To overcome the "Black Box" status of the wound-healing process, next-generation wound dressings with the abilities of real-time monitoring, diagnosis during early stages, and on-demand therapy has attracted considerable attention. Here, by combining the emerging development of bioelectronics, a smart flexible electronics-integrated wound dressing with a double-layer structure, the upper layer of which is polydimethylsiloxane-encapsulated flexible electronics integrated with a temperature sensor and ultraviolet (UV) light-emitting diodes, and the lower layer of which is a UV-responsive antibacterial hydrogel, is designed. This dressing is expected to provide early infection diagnosis via real-time wound-temperature monitoring by the integrated sensor and on-demand infection treatment by the release of antibiotics from the hydrogel by in situ UV irradiation. The integrated system possesses good flexibility, excellent compatibility, and high monitoring sensitivity and durability. Animal experiment results demonstrate that the integrated system is capable of monitoring wound status in real time, detecting bacterial infection and providing effective treatment on the basis of need. This proof-of-concept research holds great promise in developing new strategies to significantly improve wound management and other pathological diagnoses and treatments.