Inflammation-induced formation of fat-associated lymphoid clusters.
Inflammation-induced formation of fat-associated lymphoid clusters.
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DOI：
10.1038/ni.3215
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发表时间：
2015-08
影响因子：
30.5
通讯作者：
Caamaño JH
中科院分区：
文献类型：
--
作者：
Bénézech C;Luu NT;Walker JA;Kruglov AA;Loo Y;Nakamura K;Zhang Y;Nayar S;Jones LH;Flores-Langarica A;McIntosh A;Marshall J;Barone F;Besra G;Miles K;Allen JE;Gray M;Kollias G;Cunningham AF;Withers DR;Toellner KM;Jones ND;Veldhoen M;Nedospasov SA;McKenzie ANJ;Caamaño JH
脂肪相关淋巴细胞簇（FALCs）是最近发现的一种与内脏脂肪相关的淋巴组织类型。在这里我们发现FALCs的分布是不均匀的，心包中含有大量的这些簇。FALCs通过高表达趋化因子CXCL13促进B-1 B细胞在腹腔内的保留，并在腹膜免疫挑战期间支持B细胞增殖和生发中心分化。FALC的形成是由炎症诱导的，炎症触发骨髓细胞的募集，骨髓细胞表达肿瘤坏死因子（TNF），这是基质细胞中TNF受体信号传导所必需的。诱导falc的形成同样需要cd1限制的自然杀伤T （NKT）细胞。因此，在浆膜免疫应答过程中，FALCs支持和协调先天B细胞和T细胞的激活。
Fat-associated lymphoid clusters (FALCs) are a recently discovered type of lymphoid tissue associated with visceral fat. Here we show that distribution of FALCs was heterogeneous with the pericardium containing large numbers of these clusters. FALCs contributed to the retention of B-1 B cells in the peritoneal cavity through high expression of the chemokine CXCL13 and supported B cell proliferation and germinal center differentiation during peritoneal immune challenges. FALC formation was induced by inflammation, which triggered recruitment of myeloid cells that express tumor necrosis factor (TNF) necessary for TNF receptor-signaling in stromal cells. CD1d-restricted Natural killer T (NKT) cells were likewise required for inducible formation of FALCs. Thus, FALCs support and coordinate innate B and T cell activation during serosal immune responses.